A Magnetic Resonance Imaging-Based Prediction Model for Prostate Biopsy Risk Stratification

JAMA Oncology
Sherif MehralivandBaris Turkbey

Abstract

Multiparametric magnetic resonance imaging (MRI) in conjunction with MRI-transrectal ultrasound (TRUS) fusion-guided biopsies have improved the detection of prostate cancer. It is unclear whether MRI itself adds additional value to multivariable prediction models based on clinical parameters. To determine whether an MRI-based prediction model can reduce unnecessary biopsies in patients with suspected prostate cancer. Patients underwent MRI, MRI-TRUS fusion-guided biopsy, and 12-core systematic biopsy in 1 session. The development cohort used to derive the prediction model consisted of 400 patients from 1 institution enrolled between May 14, 2015, and August 31, 2016, and the validation cohort included 251 patients from 2 independent institutions who underwent biopsies between April 1, 2013, and June 30, 2016, at 1 institution and between July 1, 2015, and October 31, 2016, at the other institution. The MRI model included MRI-derived parameters in addition to clinical variables. Area under the curve of receiver operating characteristic curves and decision curve analysis were performed. Risk of clinically significant prostate cancer on biopsy, defined as a Gleason score of 3 + 4 or higher in at least 1 biopsy core. Overall, 193 (...Continue Reading

Citations

Oct 17, 2018·JAMA Oncology·Sherif MehralivandBaris Turkbey
Oct 17, 2018·JAMA Oncology·Giampaolo BianchiBernardo Rocco
Aug 14, 2018·The Journal of Urology·Baris Turkbey
Jan 11, 2019·Journal of Magnetic Resonance Imaging : JMRI·Vinay PrabhuStella K Kang
May 16, 2019·Journal of the National Comprehensive Cancer Network : JNCCN·Brandon R MasonJoseph E Ippolito
Jun 7, 2019·European Radiology·Jonathan RichenbergIvo G Schoots
Apr 26, 2019·The Cochrane Database of Systematic Reviews·Frank-Jan H DrostIvo G Schoots
Dec 14, 2019·Der Radiologe·Attila Kovács, Michael Pinkawa
Apr 11, 2020·Expert Review of Medical Devices·Luke O'ConnorBaris Turkbey
Aug 31, 2019·Current Opinion in Urology·Bishoy HannaNathan Lawrentschuk
May 13, 2020·International Journal of Cancer. Journal International Du Cancer·Sebastiaan Remmers, Monique J Roobol
Jul 4, 2018·World Journal of Urology·Guillaume PloussardUNKNOWN EAU-YAU Prostate Cancer Working Group
Mar 20, 2019·AJR. American Journal of Roentgenology·Jonathan SackettBaris Turkbey
Feb 19, 2020·BJU International·Zachary A Glaser, Soroush Rais-Bahrami
Apr 10, 2019·Nature Reviews. Urology·Kevin M KooMatt Trau
Oct 24, 2019·Current Opinion in Urology·Joseph M NorrisVeeru Kasivisvanathan
Oct 23, 2018·Therapeutic Advances in Urology·Brian L MeyersonAbhinav Sidana
Mar 28, 2019·Nature Reviews. Urology·Amir H Lebastchi, Peter A Pinto
Jun 26, 2020·World Journal of Urology·Luke P O'ConnorBaris Turkbey
Jan 30, 2019·Annual Review of Medicine·Baris Turkbey, Peter L Choyke
Nov 17, 2020·Frontiers in Genetics·Xiaoliang HuaChaozhao Liang
Jan 16, 2021·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Sadhna VermaAbhinav Sidana
Jun 27, 2020·Archives of Pathology & Laboratory Medicine·Jonathan I EpsteinKiril Trpkov
Jun 4, 2019·European Urology Oncology·Alexander P KenigsbergMarc A Bjurlin

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