A magnetic resonance imaging-based prognostic scoring system to predict outcome in transplant-eligible patients with multiple myeloma

Haematologica
Elias K MaiJens Hillengass

Abstract

Diffuse and focal bone marrow infiltration patterns detected by magnetic resonance imaging have been shown to be of prognostic significance in all stages of monoclonal plasma cell disorders and have, therefore, been incorporated into the definition of the disease. The aim of this retrospective analysis was to develop a rapidly evaluable prognostic scoring system, incorporating the most significant information acquired from magnetic resonance imaging. Therefore, the impact of bone marrow infiltration patterns on progression-free and overall survival in 161 transplant-eligible myeloma patients was evaluated. Compared to salt and pepper/minimal diffuse infiltration, moderate/severe diffuse infiltration had a negative prognostic impact on both progression-free survival (P<0.001) and overall survival (P=0.003). More than 25 focal lesions on whole-body magnetic resonance imaging or more than seven on axial magnetic resonance imaging were associated with an adverse prognosis (progression-free survival: P=0.001/0.003 and overall survival: P=0.04/0.02). A magnetic resonance imaging-based prognostic scoring system, combining grouped diffuse and focal infiltration patterns, was formulated and is applicable to whole-body as well as axial m...Continue Reading

Citations

Apr 29, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Thibaut Cassou-MounatLaurent Garderet
Jun 24, 2016·Expert Review of Hematology·Nicola LehnersMarc-Steffen Raab
Oct 6, 2017·AJR. American Journal of Roentgenology·Mario MoroneDow-Mu Koh
Jun 2, 2016·American Society of Clinical Oncology Educational Book·Evangelos TerposLia A Moulopoulos
Jul 10, 2019·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Alípio G Ormond FilhoMarcelo A C Nico
Jul 16, 2020·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·James CroftChristina Messiou
Dec 15, 2018·Journal of Magnetic Resonance Imaging : JMRI·Lia A Moulopoulos, Vassilis Koutoulidis
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