A magnetic vehicle realized tumor cell-targeted radiotherapy using low-dose radiation

Journal of Controlled Release : Official Journal of the Controlled Release Society
Hsiao-Ping ChenTse-Ying Liu

Abstract

Radiotherapy, a common cancer treatment, often adversely affects the surrounding healthy tissue and/or cells. Some tumor tissue-focused radiation therapies have been developed to lower radiation-induced lesion formation; however, achieving tumor cell-targeted radiotherapy (i.e., precisely focusing the radiation efficacy to tumor cells) remains a challenge. In the present study, we developed a novel tumor cell-targeted radiotherapy, named targeted sensitization-enhanced radiotherapy (TSER), that exploits tumor-specific folic acid-conjugated carboxymethyl lauryl chitosan/superparamagnetic iron oxide (FA-CLC/SPIO) micelles to effectively deliver chlorin e6 (Ce6, a sonosensitizer) to mitochondria of HeLa cells under magnetic guidance. For the in vitro tests, the sensitization of Ce6 induced by ultrasound, that could weaken the radiation resistant ability of tumor cells, occurred only in Ce6-internalizing tumor cells. Therefore, low-dose X-ray irradiation, that was not harmful to normal cells, could exert high tumor cell-specific killing ability. The ratio of viable normal cells to tumor cells was increased considerably, from 7.8 (at 24h) to 97.1 (at 72h), after they had received TSER treatment. Our data suggest that TSER treatment ...Continue Reading

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Citations

Apr 11, 2017·Macromolecular Bioscience·Mathias DimdeRainer Haag
Jun 24, 2017·Advanced Materials·Guosheng SongZhuang Liu
Jun 26, 2018·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·L LarueC Frochot
Jan 22, 2019·Angewandte Chemie·Mingying YangChuanbin Mao
Jun 7, 2020·International Journal of Molecular Sciences·Zaira GadzhimagomedovaAlexander Soldatov
Jun 14, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xu FangJian Liu
Dec 22, 2020·Advanced Science·Sandhya ClementEwa M Goldys
Feb 27, 2017·Journal of Controlled Release : Official Journal of the Controlled Release Society·Leyuan XuHu Yang
Jan 13, 2022·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jieyao ChenYue Pan

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