Abstract
Radiotherapy, a common cancer treatment, often adversely affects the surrounding healthy tissue and/or cells. Some tumor tissue-focused radiation therapies have been developed to lower radiation-induced lesion formation; however, achieving tumor cell-targeted radiotherapy (i.e., precisely focusing the radiation efficacy to tumor cells) remains a challenge. In the present study, we developed a novel tumor cell-targeted radiotherapy, named targeted sensitization-enhanced radiotherapy (TSER), that exploits tumor-specific folic acid-conjugated carboxymethyl lauryl chitosan/superparamagnetic iron oxide (FA-CLC/SPIO) micelles to effectively deliver chlorin e6 (Ce6, a sonosensitizer) to mitochondria of HeLa cells under magnetic guidance. For the in vitro tests, the sensitization of Ce6 induced by ultrasound, that could weaken the radiation resistant ability of tumor cells, occurred only in Ce6-internalizing tumor cells. Therefore, low-dose X-ray irradiation, that was not harmful to normal cells, could exert high tumor cell-specific killing ability. The ratio of viable normal cells to tumor cells was increased considerably, from 7.8 (at 24h) to 97.1 (at 72h), after they had received TSER treatment. Our data suggest that TSER treatment ...Continue Reading
References
Dec 15, 1992·Cancer·R F BarthR M Brugger
Apr 19, 2002·Journal of Photochemistry and Photobiology. B, Biology·M SchafferE Dühmke
Oct 25, 2003·Biochemical and Biophysical Research Communications·Ulrike KulkaGiulio Jori
Jun 3, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Rolf F BarthThomas E Blue
Oct 4, 2005·International Journal of Radiation Oncology, Biology, Physics·André Deeke SasseOtávio Augusto Camara Clark
Dec 23, 2006·Expert Opinion on Drug Delivery·Kullervo Hynynen
Feb 1, 2008·International Journal of Radiation Oncology, Biology, Physics·Yoshiya YamadaZvi Fuks
May 19, 2009·Photodiagnosis and Photodynamic Therapy·Heike J NystAlfons J M Balm
Oct 14, 2009·Biomaterials·Sonali SetuaManzoor Koyakutty
Nov 3, 2010·Journal of Photochemistry and Photobiology. B, Biology·A BoiyP A M de Witte
Jan 5, 2011·Molecular Pharmaceutics·Xiaohui ZhengWei R Chen
May 7, 2011·Bioconjugate Chemistry·Alice GalbiatiAlessandro Desideri
Oct 26, 2011·Molecular Pharmaceutics·Daiki OmataYukihiko Aramaki
Feb 10, 2012·The Journal of Investigative Dermatology·Frank LiebelMichael D Southall
Feb 14, 2012·Biomaterials·Shogo SumitaniYukio Nagasaki
Mar 13, 2012·International Journal of Medical Sciences·Rajamanickam BaskarKheng-Wei Yeoh
Apr 28, 2012·Nanoscale·Fuping GaoFangqiong Tang
Dec 21, 2012·ACS Nano·Sisi CuiYueqing Gu
Feb 12, 2013·Journal of Colloid and Interface Science·Meng XieYi Jin
Jul 9, 2013·Ultrasound in Medicine & Biology·Haiping WangQuanhong Liu
Aug 9, 2013·Journal of the American Chemical Society·Qingfeng XiaoJianlin Shi
Sep 3, 2013·Photodiagnosis and Photodynamic Therapy·Dan Dan XuWilliam Chi Shing Cho
Dec 11, 2013·Ultrasonics·Qing LiXiaobing Wang
Jan 31, 2014·International Journal of Radiation Biology·Samideh KhoeiAbdolreza Hashemian
Feb 4, 2014·Drug Discovery Today·Haijun ChenJiandong Huang
Aug 5, 2014·Journal of Biomedical Materials Research. Part a·Jyothi U MenonDebabrata Saha
Sep 30, 2014·Small·Casey McQuadeAndrew Tsourkas
Nov 2, 2014·Journal of Nanobiotechnology·Yijie ShiLiang Zhao
Nov 15, 2014·Advanced Functional Materials·Lei MiaoLeaf Huang
Dec 4, 2014·Ultrasonics Sonochemistry·Pan WangChuanshan Xu
May 2, 2015·Journal of Medicinal Chemistry·Hsiao-Ping ChenTse-Ying Liu
Citations
Apr 11, 2017·Macromolecular Bioscience·Mathias DimdeRainer Haag
Jun 24, 2017·Advanced Materials·Guosheng SongZhuang Liu
Jun 26, 2018·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·L LarueC Frochot
Jan 22, 2019·Angewandte Chemie·Mingying YangChuanbin Mao
Apr 7, 2020·Nanoscale·Fu-I TungTse-Ying Liu
Dec 31, 2016·International Journal of Molecular Medicine·Kunihiro UetaShigeru Nishizawa
Jun 7, 2020·International Journal of Molecular Sciences·Zaira GadzhimagomedovaAlexander Soldatov
Jun 14, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xu FangJian Liu
Aug 9, 2019·International Journal of Pharmaceutics·Qibo ZhangNianping Feng
Dec 22, 2020·Advanced Science·Sandhya ClementEwa M Goldys
Feb 21, 2021·Acta Biomaterialia·Chih-Sheng ChiangTse-Ying Liu
Feb 27, 2017·Journal of Controlled Release : Official Journal of the Controlled Release Society·Leyuan XuHu Yang
Jan 13, 2022·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jieyao ChenYue Pan