A major histocompatibility complex class I allele shared by two species of chimpanzee

Immunogenetics
S CooperP Parham

Abstract

Little is known regarding the rates at which natural selection can modify or retain antigen presenting alleles at the major histocompatibility complex (MHC). Discovery of identical [1101 base pairs (bp)] coding regions at the MHC class I C locus in Pan troglodytes and Pan paniscus, chimpanzee species that diverged approximately 2.3 million years ago, now indicates that a class I allotype can survive for at least this period. Remarkable conservation was also reflected in the (1799 bp) introns where a maximum of only six substitutions distinguished five alleles (three from P. troglodytes and two from P. paniscus) that encoded the identical heavy chain allotype. Analysis of a more distantly related human allele, HLA-Cw*0702, corroborated that intron variation was non-uniform along the gene. Thus we provide a clear reference frame for the lifetime of an MHC class I allotype, a direct estimate of allelic substitution rates, and evidence for an unusual evolution of MHC class I introns.

Citations

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May 13, 1999·Immunological Reviews·P Parham
Nov 1, 2008·BMC Genomics·Maxime BonhommeBrigitte Crouau-Roy
Aug 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Natasja G de GrootRonald E Bontrop
Feb 14, 2006·Immunogenetics·Gaby G M DoxiadisRonald E Bontrop
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Feb 13, 2001·Molecular Phylogenetics and Evolution·P Gagneux, A Varki
Mar 30, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Emily E WroblewskiPeter Parham
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Mar 7, 2019·Frontiers in Immunology·Emily E WroblewskiLisbeth A Guethlein
Jun 18, 2017·Immunogenetics·Natasja G de GrootRonald E Bontrop

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