PMID: 8446616Mar 1, 1993Paper

A major histocompatibility complex-linked locus in the rat critically influences resistance to diethylnitrosamine carcinogenesis

Proceedings of the National Academy of Sciences of the United States of America
M F MelhemT J Gill

Abstract

Major histocompatibility complex (MHC)-linked deletions in the rat are associated with defects in growth and development and increased susceptibility to chemical carcinogens. The present study maps a locus critical for determining susceptibility to diethylnitrosamine (DEN) carcinogenesis by using two groups of MHC-recombinant rats congenic for the MHC and its linked region. Resistance to DEN segregates with a locus (rcc+) that maps between RT1.E and ft, and its homozygous loss markedly increases susceptibility to DEN. Non-MHC genes do not significantly influence the susceptibility of these strains to DEN. The existence of the rcc locus adds support to our hypothesis that some genes in the MHC-linked region play a major role in both normal and abnormal growth.

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Citations

May 20, 1999·Transplantation Proceedings·T NatoriT J Gill
Mar 1, 1996·American Journal of Reproductive Immunology : AJRI·T J Gill
Jan 1, 1997·American Journal of Reproductive Immunology : AJRI·T J Gill
Nov 5, 1997·American Journal of Reproductive Immunology : AJRI·T J Gill
Mar 31, 1999·American Journal of Reproductive Immunology : AJRI·T J Gill
Aug 3, 1999·American Journal of Reproductive Immunology : AJRI·X J YuanT J Gill
Jun 1, 1994·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·J J RushtonT J Gill
Oct 4, 2005·Expert Opinion on Biological Therapy·Bela BodeyStuart E Siegel
Feb 24, 2010·Molecular Aspects of Medicine·Maddalena FrauRosa M Pascale
Mar 20, 2014·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Makiko OkunoIchiro Sekiya
Apr 30, 2003·Japanese Journal of Cancer Research : Gann·Motoi TakeuchiChie Furihata
Jan 1, 1994·Immunogenetics·M J KirisitsT J Gill
Jan 1, 1994·Immunogenetics·M J KirisitsT J Gill
Oct 2, 2019·Cancers·Rosa M PascaleDiego F Calvisi
May 12, 2009·Experimental Biology and Medicine·Francesco FeoRosa M Pascale
Mar 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·S IoanniduE Günther

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