A major quantitative trait locus influences hyperactivity in the WKHA rat

Nature Genetics
M P MoisanP Mormède

Abstract

The syndrome of hyperactivity describes behavioural disorders existing mainly in children and characterized by increased levels of motor activity, inattention and impulsivity. Overall the aetiology is poorly understood due to the heterogeneity of the pathology although psychological, biological and social factors acting singly or in concert are generally thought to be involved. In animal studies the observed hyperactivity phenotype results from relative participation of exploration, emotionality and general activity. Studies using brain lesions, neuropharmacology and gene knock-out strategies have shown that specific elements of the brain dopaminergic system can subserve hyperactivity. Evidence of a genetic contribution comes from family and twin studies but also from the ability to select divergent animal lines on the basis of their differential activity. The Wistar-Kyoto (WKY) and Wistar-Kyoto hyperactive (WKHA) rats are such strains--distinct for their low and high activity scores in a novel environment, respectively. Here, we report the detection of a major hyperactivity-related QTL on chromosome 8, explaining 29% of the variance of an intercross between these strains. This study represents the first behavioural QTL analysi...Continue Reading

References

Apr 1, 1992·Physiology & Behavior·H H Van DijkenF J Tilders
Oct 1, 1991·The American Journal of Physiology·G E KirschA M Brown
Jan 1, 1991·The American Journal of Psychiatry·S V FaraoneM T Tsuang
Jan 1, 1991·Journal of Child Neurology·K K Voeller
Jan 1, 1991·Journal of Child Psychology and Psychiatry, and Allied Disciplines·R Schachar
Nov 1, 1994·Genetics·G A Churchill, R W Doerge

❮ Previous
Next ❯

Citations

Sep 10, 2005·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Bastien LlamasMarie-Pierre Moisan
Apr 26, 2011·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Geison S IzídioAndré Ramos
Feb 11, 1998·Mammalian Genome : Official Journal of the International Mammalian Genome Society·M N CookM P Moisan
Dec 24, 1997·Physiology & Behavior·H SteinerD Accili
Mar 10, 1998·Neuroscience and Biobehavioral Reviews·A Ramos, P Mormède
Feb 2, 2000·Neuroscience and Biobehavioral Reviews·E D Hendley
Mar 17, 2000·Brain Research. Brain Research Reviews·M J Owen
Apr 24, 1999·Trends in Neurosciences·J C CrabbeJ K Belknap
May 1, 1997·Trends in Genetics : TIG·M R James, K Lindpaintner
Feb 6, 2002·Brain Research Bulletin·Yan ClémentCatherine Belzung
Jan 25, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Marc N PotenzaJoel Gelernter
Aug 31, 2001·ILAR Journal·Göran LevanClaude Szpirer
Aug 12, 2000·Journal of the American Academy of Child and Adolescent Psychiatry·M W StateJ F Leckman
Apr 3, 2004·Genome Research·Todd E ScheetzM Bento Soares
Jul 21, 1998·Annals of the New York Academy of Sciences·P DriscollA Tobeña
Apr 29, 1998·Annual Review of Physiology·J Floros, P Kala
Apr 5, 2002·Genome Research·Alberto Fernández-TeruelJonathan Flint
Jul 29, 2008·Behavioural Brain Research·M CecchiH Akil
Mar 1, 2008·Journal of Neuroscience Methods·Vladimir S NaumenkoAlexander V Kulikov
Dec 9, 2004·Journal of Neuroscience Methods·Alexander V KulikovNina K Popova
Dec 24, 1997·Genomics·H K Gershenfeld, S M Paul
Jul 1, 1998·Brain, Behavior, and Immunity·R H BonneauB C Jones
Dec 26, 2001·Annual Review of Psychology·John C Crabbe
Nov 6, 2004·Neuroscience and Biobehavioral Reviews·P HeiserJ Hebebrand
Mar 14, 1998·Experimental Animals·T SerikawaJ L Guénet
Jul 30, 2003·Genes, Brain, and Behavior·J MillP Asherson
Dec 18, 2002·Journal of Neurobiology·Jonathan Flint
Apr 23, 2003·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Sarah CurranPak Sham
Nov 10, 2006·Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie·Benno Graf SchimmelmannJohannes Hebebrand
Mar 7, 2001·Genome Research·T E ScheetzV C Sheffield
May 13, 1999·Nature Genetics·T K WatanabeM R James
May 1, 1997·Genome Research·M T BihoreauG M Lathrop
Apr 11, 2003·Neurogenetics·Deborah A FinnJohn C Crabbe
Aug 27, 2005·Doklady Biological Sciences : Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections·V S NaumenkoN K Popova

❮ Previous
Next ❯

Related Concepts

Related Feeds

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.