PMID: 8947548Dec 1, 1996Paper

A major transmembrane protein of Golgi-derived COPI-coated vesicles involved in coatomer binding

The Journal of Cell Biology
K SohnF T Wieland

Abstract

Formation of non-clathrin-coated vesicles requires the recruitment of several cytosolic factors to the Golgi membrane. To identify membrane proteins involved in this budding process, a highly abundant type I transmembrane protein (p23) was isolated from mammalian Golgi-derived COPI-coated vesicles, and its cDNA was cloned and sequenced. It belongs to the p24 family of proteins involved in the budding of transport vesicles (Stamnes, M.A., M.W. Craighead, M.H. Hoe, N. Lampen, S. Geromanos, P. Tempst, and J.E. Rothman. 1995. Proc. Natl. Acad. Sci. USA. 92:8011-8015). p23 consists of a large NH2-terminal luminal domain and a short COOH-terminal cytoplasmic tail (-LRRFFKAKKLIE-CO2-) that shows similarity, but not identity, with the sequence motif-KKXX-CO2-, known as a signal for retrieval of escaped ER-resident membrane proteins (Jackson, M.R., T. Nilsson, and P.A. Peterson. 1990. EMBO (Eur. Mol. Biol. Organ.) J. 9:3153-3162; Nilsson, T., M. Jackson, and P.A. Peterson. 1989. Cell. 58:707-718). The cytoplasmic tail of p23 binds to coatomer with similar efficiency as known KKXX motifs. However, the p23 tail differs from the KKXX motif in having an additional motif needed for binding of coatomer. p23 is localized to Golgi cisternae and...Continue Reading

References

Dec 1, 1978·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J RothL Orci
Apr 1, 1992·The Journal of Cell Biology·D JeckelF Wieland
Jul 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·J G DonaldsonR D Klausner
Aug 1, 1986·Journal of Microscopy·K T Tokuyasu
Mar 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·J E BergmannS J Singer
Aug 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·S Yokota, H D Fahimi
Nov 15, 1981·Journal of Molecular Biology·J GreenG Warren
May 5, 1982·Journal of Molecular Biology·J Kyte, R F Doolittle
Oct 1, 1995·The Journal of Cell Biology·C ItinH P Hauri
Aug 15, 1995·Proceedings of the National Academy of Sciences of the United States of America·M A StamnesJ E Rothman
Apr 11, 1995·Proceedings of the National Academy of Sciences of the United States of America·B GerichC Harter
Nov 3, 1994·Nature·J E Rothman
Dec 30, 1994·Cell·H R Pelham
Feb 1, 1994·The Journal of Cell Biology·P SlusarewiczG Warren
Mar 1, 1994·The Journal of Cell Biology·S Hara-KugeJ E Rothman
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·L OrciJ E Rothman
Apr 1, 1993·The Journal of Cell Biology·A OprinsJ W Slot
Apr 1, 1993·The Journal of Cell Biology·M R JacksonP A Peterson
May 1, 1993·The Journal of Cell Biology·J B HelmsJ E Rothman
Dec 29, 1995·The Journal of Biological Chemistry·M Lowe, T E Kreis
Apr 12, 1996·Science·J E Rothman, F T Wieland
Mar 5, 1996·Proceedings of the National Academy of Sciences of the United States of America·C HarterF Wieland

❮ Previous
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Citations

Oct 17, 2006·The Journal of Membrane Biology·J BéthuneJ Moelleken
Dec 14, 2011·Protoplasma·Nathanael P Cottam, Daniel Ungar
May 30, 2001·Molecular and Biochemical Parasitology·A G MaierC Clayton
Mar 15, 2001·Current Opinion in Cell Biology·J W Erickson, R A Cerione
Aug 1, 1997·Current Opinion in Cell Biology·M J Kuehn, R Schekman
Aug 1, 1997·Current Opinion in Cell Biology·T KirchhausenH Riezman
Aug 8, 1998·Trends in Cell Biology·S I BannykhW E Balch
Apr 1, 2000·Microbes and Infection·A Liendo, K A Joiner
Mar 19, 2009·Nature Reviews. Molecular Cell Biology·Victor W HsuJia-Shu Yang
Aug 12, 2008·Proceedings of the National Academy of Sciences of the United States of America·Rainer BeckFelix Wieland
Jan 26, 2011·The Journal of Biological Chemistry·Qian SunRichard D Cummings
Apr 2, 2011·The Journal of Biological Chemistry·HongBin WangMarcelo G Kazanietz
Mar 22, 2002·Molecular Biology of the Cell·Jacqueline Powers, Charles Barlowe
Feb 21, 2002·Molecular Biology of the Cell·Raymond V FuciniMark Stamnes
Jun 8, 1999·Molecular Biology of the Cell·M MarziochA Rowley
Jun 16, 2001·Molecular Biology of the Cell·I GkantiragasJ B Helms
Dec 8, 1998·Molecular Biology of the Cell·N NakamuraK Mihara
Jan 26, 2007·Molecular Biology of the Cell·Xueyi LiJ Bernd Helms
Feb 19, 2010·Molecular Biology of the Cell·Hongbin Wang, Marcelo G Kazanietz
Jun 18, 2011·Molecular Biology of the Cell·Guillaume A CastillonManuel Muñiz
May 12, 2012·Journal of Experimental Botany·Juan Carlos MontesinosFernando Aniento
May 12, 2009·Molecular Biology and Evolution·Jeroen R P M StratingGerard J M Martens
Aug 17, 2011·Cold Spring Harbor Perspectives in Biology·Vincent PopoffFelix Wieland
Oct 14, 2000·Annual Review of Cell and Developmental Biology·J Lippincott-SchwartzK Hirschberg
Feb 10, 2007·Molecular Neurodegeneration·Kulandaivelu S VetrivelGopal Thinakaran
Mar 8, 2011·Molecular Neurodegeneration·Shengchun LiuWeihong Song
Apr 10, 2008·PloS One·Satish Arcot JayaramChristos Samakovlis
Oct 30, 1999·Biological Chemistry·M H SkowronekI G Haas
Sep 10, 2013·International Journal of Molecular Sciences·Birsen Cevher-Keskin
May 9, 2000·Biochemical and Biophysical Research Communications·M WeidlerP Rösch
Oct 23, 1997·Proceedings of the National Academy of Sciences of the United States of America·W NickelF T Wieland
Nov 13, 1998·Proceedings of the National Academy of Sciences of the United States of America·M StamnesJ E Rothman
Sep 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·C Harter, F T Wieland
Mar 29, 2000·Proceedings of the National Academy of Sciences of the United States of America·S SpringerR Schekman
Feb 7, 1998·Proceedings of the National Academy of Sciences of the United States of America·A SchweizerJ Rohrer
Apr 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·J PavelF T Wieland
Feb 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·C ReinhardF Wieland

❮ Previous
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