A malignant solitary fibrous tumour arising from the first lumbar vertebra and mimicking an osteosarcoma: a case report

World Journal of Surgical Oncology
Naoki OikeNaoto Endo

Abstract

A solitary fibrous tumour (SFT) is an unusual neoplasm typically found in soft tissues. Although SFTs can arise in the bones, they very rarely arise in the vertebral arch. Here, we describe a case of a SFT that arose in the vertebral arch of the first lumbar (L1) spinal vertebrae and mimicked osteosarcoma. A 49-year-old woman presented with a 2-month history of lower back pain and a lumbar region mass. Magnetic resonance imaging demonstrated a heterogeneously enhanced mass in the L1 vertebral arch. The patient received neoadjuvant chemotherapy, followed by a surgical procedure comprising an anterior spinal fusion and en bloc resection. Histologically, our initial diagnosis was osteosarcoma. The postoperative course was uneventful, and the patient received adjuvant chemotherapy. However, the tumour metastasised to the lung 5 years after the first surgery, and a second surgery was performed for lung tumour resection. The histology of the metastatic lung tumour appeared similar to that of the malignant SFT, and the specimen from the first surgery was re-examined. Immunohistochemically, the tumour was positive for STAT6. Reverse transcription-polymerase chain reaction revealed a NAB2-STAT6 fusion gene, thus confirming our final dia...Continue Reading

References

Dec 16, 1998·The American Journal of Surgical Pathology·A V Vallat-DecouvelaereC D Fletcher
May 23, 2008·Spine·Eva MuñozClaudia Valverde
Apr 28, 2010·The American Journal of Surgical Pathology·Sofie L J VerbekeJudith V M G Bovée
Oct 25, 2012·Orthopaedics & Traumatology, Surgery & Research : OTSR·B BouyerP Guigui
Nov 28, 2013·Journal of Korean Neurosurgical Society·Seong SonChan Jong Yoo
Jan 25, 2014·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Leona A DoyleAdrián Mariño-Enríquez
Aug 1, 2015·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Hui-Chun TaiHsuan-Ying Huang

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Citations

Jul 3, 2018·International Journal of Surgical Pathology·David A Suarez-ZamoraMauricio A Palau-Lazaro
Jun 11, 2020·Skeletal Radiology·Cassie JiaLester J Layfield
Dec 29, 2020·Radiology Case Reports·Terence VerlaAlexander E Ropper
May 3, 2021·Echocardiography·Ali SheikhyMasih Tajdini

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Methods Mentioned

BETA
biopsy
PCR
surgical resection

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