PMID: 8610109Apr 2, 1996Paper

A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain

Proceedings of the National Academy of Sciences of the United States of America
J P O'BryanT Pawson

Abstract

The Shc adaptor protein, hereafter referred to as ShcA, possesses two distinct phosphotyrosine-recognition modules, a C-terminal Src homology 2 (SH2) domain and an N-terminal phosphotyrosine-binding (PTB) domain, and is itself phosphorylated on tyrosine in response to many extracellular signals. Phosphorylation of human ShcA at Tyr-317 within its central (CH1) region induces binding to the Grb2 SH2 domain and is thereby implicated in activation of the Ras pathway. Two shc-related genes (shcB and shcC) have been identified in the mouse. shcB is closely related to human SCK, while shcC has not yet been found in other organisms. The ShcC protein is predicted to have a C-terminal SH2 domain, a CH1 region with a putative Grb2-binding site, and an N-terminal PTB domain. The ShcC and ShcB SH2 domains bind phosphotyrosine-containing peptides and receptors with a specificity related to, but distinct from, that of the ShcA SH2 domain. The ShcC PTB domain specifically associates in vitro with the autophosphorylated receptors for nerve growth factor and epidermal growth factor. These results indicate that ShcC has functional SH2 and PTB; domains. In contrast to shcA, which is widely expressed, shcC RNA and proteins are predominantly expres...Continue Reading

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Citations

Nov 26, 1998·Trends in Neurosciences·E Cattaneo, P G Pelicci
Apr 29, 1998·Brain Research. Molecular Brain Research·K TanabeH Kiyama
Mar 12, 2004·Cancer Letters·Masatoshi IchiharaMasahide Takahashi
Sep 30, 1998·The European Journal of Neuroscience·P GanjuI F James
Aug 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jerome AubertAustin Smith
Jan 29, 2002·The Journal of Biological Chemistry·Karen K Cook, Debra A Fadool
Apr 25, 2007·Molecular and Cellular Biology·Nina JonesTony Pawson
Jan 17, 2014·Molecular Biology of the Cell·Melanie K B WillsNina Jones
Apr 17, 2001·Biochemical and Biophysical Research Communications·K SakaguchiM Kasuga
Jul 22, 1997·Proceedings of the National Academy of Sciences of the United States of America·L ContiE Cattaneo
Oct 21, 2004·Proceedings of the National Academy of Sciences of the United States of America·Flavia TroglioGiuliana Pelicci
Dec 15, 2015·The Journal of Pharmacology and Experimental Therapeutics·Mehrnoosh SooriRobert W Mason
Dec 2, 2011·Archives of Gerontology and Geriatrics·Kiyoaki SoneNozomu Mori
Aug 12, 2009·Biochemical and Biophysical Research Communications·Masashi WatanabeShigetsugu Hatakeyama
Nov 17, 2009·Immunological Reviews·Francesca FinettiCosima T Baldari
Oct 9, 2007·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·V VillanacciG Pelicci
Feb 9, 2012·Stem Cells·Barbara OrtensiGiuliana Pelicci
Dec 1, 2010·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Steve P HawleyNina Jones
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May 23, 2001·Nature Neuroscience·L ContiE Cattaneo

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