A mammalian homolog of unc-53 is regulated by all-trans retinoic acid in neuroblastoma cells and embryos

Proceedings of the National Academy of Sciences of the United States of America
Ronald A MerrillMargaret Clagett-Dame

Abstract

The vitamin A metabolite, all-trans retinoic acid (atRA), plays an important role in neuronal development, including neurite outgrowth. However, the genes that lie downstream of atRA and its receptors in neuronal cells are largely unknown. By using the human neuroblastoma cell line, SH-SY5Y, we have identified an atRA-responsive gene (RAINB1: retinoic acid inducible in neuroblastoma cells) that is induced within 4 h after exposure of SH-SY5Y cells to atRA. RAINB1 mRNA is highly expressed in the nervous system (10.5- to 11-kb transcript) in both developing embryos and adults. Its expression is perturbed in developing rat embryos exposed to excess or insufficient atRA. RAINB1 is present on chromosome 11 and is spread over 38 exons, resulting in a putative ORF of 2,429 amino acids. The RAINB1 protein shows high similarity to a gene in Caenorhabditis elegans, unc-53, that is required for axonal elongation of mechanosensory neurons, suggesting that these proteins are orthologs. Thus, RAINB1 may represent a critical downstream gene in atRA-mediated neurite outgrowth.

References

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Citations

Mar 31, 2005·Molecular and Cellular Neurosciences·María José Martínez-LópezCarlos Buesa
Feb 27, 2010·Neural Development·Elizabeth M McNeillMargaret Clagett-Dame
Jan 19, 2012·Nutrients·Margaret Clagett-Dame, Danielle Knutson
Sep 10, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Shunsuke IwanoYohei Miyamoto
Aug 30, 2008·Developmental Neurobiology·P D MuleyM Clagett-Dame
Oct 26, 2012·Genes, Chromosomes & Cancer·Emilia CarlssonAnnamari Ranki
May 26, 2004·Brain Research. Developmental Brain Research·Pieter J PeetersDieder W E Moechars
Oct 11, 2015·Journal of Experimental & Clinical Cancer Research : CR·Fengbo TanHaiping Pei
Mar 23, 2011·Developmental Biology·Elizabeth M McNeillMargaret Clagett-Dame
Sep 18, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Ronald A MerrillMargaret Clagett-Dame
Dec 12, 2018·JAMA : the Journal of the American Medical Association·Seung Hoan ChoiUNKNOWN DiscovEHR study and the NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium
May 12, 2006·Journal of Neurobiology·Margaret Clagett-DameParag D Muley
May 3, 2019·Cell Communication and Signaling : CCS·Thabat KhatibPeter McCaffery
Jun 5, 2020·The Journal of Cell Biology·Carlos Sánchez-HuertasJérôme Boudeau
Oct 15, 2011·Experimental Dermatology·Pilvi MaliniemiAnnamari Ranki
Jan 27, 2009·Development·Kristopher L SchmidtEve G Stringham
Jul 1, 2008·Archives of Biochemistry and Biophysics·D C Knutson, M Clagett-Dame

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