A manic episode with psychotic features improved by methylprednisolone in a patient with multiple sclerosis

General Hospital Psychiatry
Sevan HotierOlivier Guillin

Abstract

Several studies have reported a higher prevalence of unipolar depression and bipolar disorder among patients with multiple sclerosis (MS). However, only a few studies have reported manic episodes concomitant with new lesions enhanced by gadolinium on brain magnetic resonance imaging (MRI). Here we report the case of a 47-year-old woman suffering from MS admitted for a manic episode with psychotic features. Brain MRI revealed three new T2 lesions enhanced by gadolinium located in the corpus callosum and in ventromedial prefrontal regions. She rapidly recovered with intravenous methylprednisolone in combination with risperidone. In conclusion, in this patient, the fact that gadolinium-enhancing lesion coincided with new symptoms which responded quickly to corticosteroids suggests that the manic episode was an acute manifestation of MS.

References

Jun 17, 2008·Revue neurologique·B El MoutawakilI Slassi
Sep 9, 2009·Revue neurologique·F BlancJ de Seze
Mar 18, 2010·International Review of Psychiatry·Thomas PaparrigopoulosGeorge N Papadimitriou
Feb 9, 2012·Trends in Cognitive Sciences·Mathieu RoyTor D Wager
Dec 4, 2013·Journal of Affective Disorders·M G CartaM G Marrosu
May 16, 2014·Behavioural Neurology·Youssef SidhomRiadh Gouider
Jan 15, 2015·Multiple Sclerosis : Clinical and Laboratory Research·Ruth Ann MarrieNadia Reider

❮ Previous
Next ❯

Citations

Mar 30, 2017·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Moussa A Chalah, Samar S Ayache
Nov 17, 2016·Current Neurology and Neuroscience Reports·Aaron P TurnerDawn M Ehde

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.