A map of the SARS-CoV-2 RNA structurome.

NAR Genomics and Bioinformatics
Ryan J AndrewsWalter N Moss


SARS-CoV-2 has exploded throughout the human population. To facilitate efforts to gain insights into SARS-CoV-2 biology and to target the virus therapeutically, it is essential to have a roadmap of likely functional regions embedded in its RNA genome. In this report, we used a bioinformatics approach, ScanFold, to deduce the local RNA structural landscape of the SARS-CoV-2 genome with the highest likelihood of being functional. We recapitulate previously-known elements of RNA structure and provide a model for the folding of an essential frameshift signal. Our results find that SARS-CoV-2 is greatly enriched in unusually stable and likely evolutionarily ordered RNA structure, which provides a large reservoir of potential drug targets for RNA-binding small molecules. Results are enhanced via the re-analyses of publicly-available genome-wide biochemical structure probing datasets that are broadly in agreement with our models. Additionally, ScanFold was updated to incorporate experimental data as constraints in the analysis to facilitate comparisons between ScanFold and other RNA modelling approaches. Ultimately, ScanFold was able to identify eight highly structured/conserved motifs in SARS-CoV-2 that agree with experimental data, ...Continue Reading


Sep 27, 1994·Proceedings of the National Academy of Sciences of the United States of America·A E WalterM Zuker
Jan 10, 2003·Nucleic Acids Research·Sam Griffiths-JonesSean R Eddy
Jun 26, 2003·Nucleic Acids Research·Michael Zuker
Dec 21, 2004·Nucleic Acids Research·Sam Griffiths-JonesAlex Bateman
May 12, 2005·PLoS Biology·Ewan P PlantJonathan D Dinman
Oct 6, 2005·BMC Bioinformatics·Eva FreyhultVincent Moulton
Apr 25, 2007·Nucleic Acids Research·Andreas R GruberStefan Washietl
Aug 21, 2008·Methods in Molecular Biology·Nicholas R Markham, Michael Zuker
Oct 28, 2008·Nucleic Acids Research·Paul P GardnerAlex Bateman
Dec 26, 2008·Proceedings of the National Academy of Sciences of the United States of America·Katherine E DeiganKevin M Weeks
Mar 25, 2009·Bioinformatics·Eric P NawrockiSean R Eddy
Apr 29, 2009·Bioinformatics·Kévin DartyYann Ponty
Aug 8, 2009·Nature·Joseph M WattsKevin M Weeks
Mar 17, 2010·BMC Bioinformatics·Jessica S Reuter, David H Mathews
Oct 19, 2011·Nucleic Acids Research·Brett E PickettRichard H Scheuermann
Nov 26, 2011·Algorithms for Molecular Biology : AMB·Ronny LorenzIvo L Hofacker
Mar 1, 2012·Nucleic Acids Research·Sita J LangeRolf Backofen
Apr 21, 2012·Briefings in Bioinformatics·Helga ThorvaldsdóttirJill P Mesirov
Oct 24, 2012·PloS One·Kourosh ZarringhalamPeter Clote
Nov 6, 2012·Nucleic Acids Research·Sarah W BurgeAlex Bateman
Apr 27, 2013·Nucleic Acids Research·Stanislav BellaousovDavid H Mathews
Sep 7, 2013·Bioinformatics·Eric P Nawrocki, Sean R Eddy
Jan 1, 2012·Genes·Felipe A LessaPeter F Stadler
Nov 14, 2014·Nucleic Acids Research·Eric P NawrockiRobert D Finn
Mar 5, 2015·Virus Research·Dong Yang, Julian L Leibowitz
Apr 12, 2016·Methods : a Companion to Methods in Enzymology·Ronny LorenzIvo L Hofacker
Sep 26, 2016·Methods in Molecular Biology·Zhenjiang Zech Xu, David H Mathews
Jul 28, 2016·Diseases·Torstein Tengs, Christine M Jonassen
Nov 8, 2017·Nucleic Acids Research·Ioanna KalvariAnton I Petrov
Mar 31, 2019·Nature Communications·Roland G HuberYue Wan
Sep 16, 2019·Current Opinion in Structural Biology·David MitchellPhilip C Bevilacqua
Nov 13, 2019·Methods : a Companion to Methods in Enzymology·Ryan J AndrewsWalter N Moss

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Landau-Kleffner Syndrome

Landau Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, or aphasia with convulsive disorder, is a rare childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram. Discover the latest research on LKS here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Related Papers

BioRxiv : the Preprint Server for Biology
Ryan J AndrewsW. N. Moss
BioRxiv : the Preprint Server for Biology
Ryan J AndrewsWalter N Moss
Methods : a Companion to Methods in Enzymology
Ryan J AndrewsWalter N Moss
© 2021 Meta ULC. All rights reserved