PMID: 9194271Jun 15, 1997Paper

A marginal regression modelling framework for evaluating medical diagnostic tests

Statistics in Medicine
W LeisenringG Longton

Abstract

Technological advances continue to develop for early detection of disease. Research studies are required to define the statistical properties of such screening or diagnostic tests. However, statistical methodology currently used to evaluate diagnostic tests is limited. We propose the use of marginal regression models with robust sandwich variance estimators to make inference about the sensitivity and specificity of diagnostic tests. This method is more flexible than standard methods in that it allows comparison of sensitivity between two or more tests even if all tests are not carried out on all subjects, it can accommodate correlated data, and the effect of covariates can be evaluated. This last feature is important since it allows researchers to understand the effects on sensitivity and specificity of various environmental and patient characteristics. If such factors are under the control of the clinician, it provides the opportunity to modify the diagnostic testing program to maximize sensitivity and/or specificity. We show that the marginal regression modelling methods generalize standard statistical methods. In particular, when we compare two screening tests and we test each subject with both screens, the method correspond...Continue Reading

Citations

Oct 25, 2012·Radiology·Tessa S S GendersM G Myriam Hunink
Nov 3, 1998·Journal of General Internal Medicine·E EtchellsS Siu
Aug 21, 2008·Biostatistics·Wen Gu, Margaret Sullivan Pepe
May 24, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kieren A MarrWendy Leisenring
Aug 19, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kieren A Marr, Wendy Leisenring
Sep 14, 2000·Biometrics·C J Lloyd
Mar 1, 2002·Statistics in Medicine·Todd A AlonzoChaya S Moskowitz
Sep 21, 2007·International Journal of Radiation Oncology, Biology, Physics·Masoom A HaiderMichael Milosevic
Jun 24, 2003·Statistics in Medicine·Huiman X Barnhart, Andrzej S Kosinski
Aug 22, 2009·Biometrical Journal. Biometrische Zeitschrift·Alexander R de LeonChristopher J Rudnisky
Apr 5, 2003·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Torsten SchäferJoachim Heinrich
Oct 18, 2007·Statistics in Medicine·Lori E Dodd, Edward L Korn
Feb 1, 2006·The British Journal of Dermatology·I ZalaudekUNKNOWN DERMOSCOPY WORKING GROUP
Jul 6, 2013·Biometrical Journal. Biometrische Zeitschrift·Daniela Wenzel, Antonia Zapf
Jun 15, 2005·American Journal of Ophthalmology·Felipe A MedeirosRobert N Weinreb
Aug 14, 2015·Open Forum Infectious Diseases·Dennis G FisherTodd A Alonzo
Sep 21, 2013·Translational Vision Science & Technology·Errol Wei'en ChanChing-Yu Cheng
Oct 30, 2014·International Urogynecology Journal·Peggy A NortonL Cannon-Albright
Jul 25, 2007·AJR. American Journal of Roentgenology·Masoom A HaiderJohn Trachtenberg
Apr 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Giuseppe ArgenzianoJosep Malvehy
Apr 9, 2017·BMC Medical Research Methodology·Adina Najwa KamarudinRuwanthi Kolamunnage-Dona
May 25, 2004·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Guangyong Zou
Dec 14, 2011·Journal of Clinical Microbiology·Morgan A MarksPatti E Gravitt
Nov 11, 2006·Biometrical Journal. Biometrische Zeitschrift·Carol Y LinAndrzej S Kosinski
Oct 30, 2018·Biometrical Journal. Biometrische Zeitschrift·John S PreisserHaitao Chu

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