A Markov cost-effective analysis of biannual fluoride varnish for preventing dental caries in permanent teeth over a 70-year time horizon.

Health Promotion Journal of Australia : Official Journal of Australian Association of Health Promotion Professionals
Tan Minh NguyenDanny Liew

Abstract

Biannual application of fluoride varnish is effective for dental caries prevention, but its cost-effectiveness using quality-adjusted life years (QALY) is unknown. This study performed a cost-effectiveness analysis, from the Australian health care system perspective of biannual application of fluoride varnish versus current practice (non-routine application) for an individual aged 15 years and older over a 70-year time horizon. Health outcomes measured were the number of prevented decayed, missing, and filled teeth (prevented-DMFT) and QALY gained. The calculated incremental cost-effectiveness ratio (ICER) was compared against the reference cost-effectiveness ICER threshold of AUD$28 033 per QALY gained. A published Markov model capturing dental caries progression of eight permanent molars was used. This 6-monthly cycle model represented ten possible health states for an individual tooth. A 5% discount rate was applied with relevant sensitivity analysis. In the base-case scenario, the net cost for the intervention was $3600 compared to $2303 in the current practice arm. The intervention arm yielded 13.99 DMFT and 15.44 QALY gained, whereas the current practice arm yielded 15.52 DMFT and 14.74 QALY gained. The estimated ICER was...Continue Reading

References

Feb 1, 1996·Community Dentistry and Oral Epidemiology·J M Lewis
Feb 2, 1994·Medical Care Review·H H Schauffler, T Rodriguez
Mar 9, 1993·PharmacoEconomics·D A Katz, H G Welch
Sep 11, 2008·Australian Dental Journal·M S HopcraftF A C Wright
Sep 1, 2009·Advances in Dental Research·J D B Featherstone
Jun 3, 2010·The Journal of the American Dental Association·Joseph L RileyUNKNOWN Dental Practice-Based Research Network Collaborative Group
Jun 22, 2010·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Emma WarrenEli Schwarz
Jul 13, 2013·The Cochrane Database of Systematic Reviews·Valeria C C MarinhoJan E Clarkson
Dec 3, 2014·Chemosphere·Junjie Shen, Andrea Schäfer
Jan 9, 2015·Perspectives in Public Health·Lee Knifton
Mar 3, 2015·International Journal of Dental Hygiene·G Hänsel PeterssonS Twetman
Jun 18, 2015·Journal of Dental Research·U TonmukayakulC M Faggion
Jan 18, 2017·Journal of Clinical and Translational Hepatology·Shaina M Lynch, George Y Wu
Jun 24, 2017·Journal of Dental Research·B T PahelR G Rozier
Jul 7, 2017·Community Dentistry and Oral Epidemiology·Falk SchwendickeLyndie Foster Page
Dec 24, 2017·PharmacoEconomics·Laura Catherine EdneyJonathan Karnon
Jul 1, 2017·JDR Clinical and Translational Research·T M NguyenS Koshy

❮ Previous
Next ❯

Citations

Dec 29, 2020·Acta Odontologica Scandinavica·Thomas DavidsonSofia Tranæus

❮ Previous
Next ❯

Methods Mentioned

BETA
PBAC

Software Mentioned

Excel
Office Professional Plus

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.