A mass and solute balance model for tear volume and osmolarity in the normal and the dry eye

Progress in Retinal and Eye Research
E A GaffneyA J Bron

Abstract

Tear hyperosmolarity is thought to play a key role in the mechanism of dry eye, a common symptomatic condition accompanied by visual disturbance, tear film instability, inflammation and damage to the ocular surface. We have constructed a model for the mass and solute balance of the tears, with parameter estimation based on extensive data from the literature which permits the influence of tear evaporation, lacrimal flux and blink rate on tear osmolarity to be explored. In particular the nature of compensatory events has been estimated in aqueous-deficient (ADDE) and evaporative (EDE) dry eye. The model reproduces observed osmolarities of the tear meniscus for the healthy eye and predicts a higher concentration in the tear film than meniscus in normal and dry eye states. The differential is small in the normal eye, but is significantly increased in dry eye, especially for the simultaneous presence of high meniscus concentration and low meniscus radius. This may influence the interpretation of osmolarity values obtained from meniscus samples since they need not fully reflect potential damage to the ocular surface caused by tear film hyperosmolarity. Interrogation of the model suggests that increases in blink rate may play a limite...Continue Reading

References

Sep 1, 1979·Archives of Ophthalmology·J P Gilbard, R L Farris
Apr 1, 1978·Archives of Ophthalmology·J P GilbardJ Santamaria
Mar 1, 1992·The British Journal of Ophthalmology·G Rieger
Oct 1, 1991·Experimental Eye Research·E A Macdonald, D M Maurice
Jul 15, 1989·American Journal of Ophthalmology·K Tsubota
Jan 1, 1987·International Ophthalmology Clinics·M A Lemp
May 10, 1973·Experimental Eye Research·F J Holly
Jul 30, 1971·American Journal of Ophthalmology·J E McDonald, S Brubaker
Jun 1, 1968·Archives of Ophthalmology·J L BaumS A Boruchoff
Oct 1, 1984·Ophthalmology·J P GilbardK R Kenyon
Feb 1, 1995·Archives of Ophthalmology·K Tsubota, K Nakamori
Jan 1, 1994·International Ophthalmology Clinics·J P Gilbard
Dec 1, 1996·Journal of Colloid and Interface Science·H WongC J Radke
Jul 1, 1997·American Journal of Ophthalmology·K NakamoriK Tsubota
Aug 26, 1998·Ophthalmology·J ShimazakiK Tsubota
Oct 20, 1998·Progress in Retinal and Eye Research·K Tsubota
Dec 5, 1998·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·K TsubotaT Takeuchi
Apr 21, 1999·The British Journal of Ophthalmology·N YokoiC Fowler
Dec 28, 1999·The British Journal of Ophthalmology·M Goebbels
Sep 29, 2000·Cornea·S C PflugfelderM E Stern
Sep 29, 2000·Cornea·J P McCulley, W E Shine
Feb 28, 2001·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·A TomlinsonK Blades
May 1, 2001·Optometry and Vision Science : Official Publication of the American Academy of Optometry·A TomlinsonE I Pearce
Oct 6, 2001·Survey of Ophthalmology·A J Bron
Nov 16, 2002·Progress in Retinal and Eye Research·Darlene A Dartt
Jan 31, 2003·Investigative Ophthalmology & Visual Science·Eiki GotoKazuo Tsubota
Feb 14, 2003·Archives of Ophthalmology·Eiki Goto, Scheffer C G Tseng
Apr 30, 2003·American Journal of Ophthalmology·Tomoko GotoYuichi Ohashi
Sep 17, 2003·Mathematical Medicine and Biology : a Journal of the IMA·R J Braun, A D Fitt
Oct 28, 2003·Investigative Ophthalmology & Visual Science·Carolyn G BegleyTrefford Simpson
Apr 27, 2004·Experimental Eye Research·A J BronL W Voon
Apr 27, 2004·Experimental Eye Research·Michael E SternStephen C Pflugfelder
Apr 28, 2004·Investigative Ophthalmology & Visual Science·Takashi KojimaKazuo Tsubota
Sep 3, 2004·Health and Quality of Life Outcomes·Susan VitaleJanine A Smith
Sep 15, 2004·Archives of Ophthalmology·Norihiko YokoiShigeru Kinoshita
Sep 30, 2004·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Mitrofanis PavlidisSolon Thanos
Dec 14, 2004·Current Eye Research·P Ewen King-SmithJohn M Tiffany
Feb 9, 2005·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Feisal A AdatiaAllan Slomovic
Apr 19, 2005·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Yogesh GuptaMohit Gupta
Apr 27, 2005·Survey of Ophthalmology·Clayton BlehmRichard W Yee

❮ Previous
Next ❯

Citations

Jul 4, 2013·Bulletin of Mathematical Biology·V S ZubkovE A Gaffney
Aug 8, 2012·Eye & Contact Lens·Ming LiJianhua Wang
May 25, 2012·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Gemma JulioMaría Dolores Merindano
Apr 29, 2011·American Journal of Physiology. Cell Physiology·Lilian ChiangSarah F Hamm-Alvarez
Feb 7, 2013·Investigative Ophthalmology & Visual Science·Anat GalorVictor L Perez
Mar 28, 2013·Investigative Ophthalmology & Visual Science·Carolyn BegleyPing Situ
Dec 3, 2014·Progress in Retinal and Eye Research·A J BronF V Bright
Feb 14, 2013·Current Eye Research·Adam KeechLyndon Jones
Apr 15, 2014·The Ocular Surface·Anthony J BronMichael A Lemp
Jul 31, 2012·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Colin CerretaniC J Radke
Mar 8, 2016·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Hugo Pena-VerdealEva Yebra-Pimentel
Oct 25, 2011·American Journal of Ophthalmology·Stephen C Pflugfelder
Jun 19, 2014·Cutaneous and Ocular Toxicology·Emine Kalkan AkcayNurullah Cagil
Feb 8, 2014·Current Eye Research·Colin F Cerretani, C J Radke
Dec 6, 2014·Progress in Retinal and Eye Research·R J BraunN R Gewecke
Apr 13, 2017·Lab on a Chip·Zachary EstlackJungkyu Kim
Sep 1, 2015·Advances in Colloid and Interface Science·Samuel GauseAnuj Chauhan
Mar 1, 2017·Korean Journal of Ophthalmology : KJO·Mirinae KimKyung-Sun Na
Oct 17, 2017·Mathematical Medicine and Biology : a Journal of the IMA·Longfei LiP E King-Smith
Jan 26, 2018·The British Journal of Ophthalmology·Andrea LeonardiIva Fregona
Jul 26, 2014·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Stefan BandlitzHeiko Pult
Nov 28, 2018·Investigative Ophthalmology & Visual Science·Norihiko Yokoi, Georgi As Georgiev
Sep 29, 2017·Cornea·Reiko AritaNaoyuki Morishige
Jul 24, 2015·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Wing LiMeng C Lin
Oct 29, 2013·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Stefan BandlitzAnthony J Bron
Aug 29, 2018·Therapeutic Advances in Ophthalmology·Ali A AbusharhaAli M Masmali
Jun 13, 2015·The Open Ophthalmology Journal·George L SpaethAna Figueiredo
Oct 14, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wan Seok KangJunghyun Kim
Oct 1, 2015·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Laura E Downie, Peter R Keller
Mar 11, 2021·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Britta NiedernolteStefan Bandlitz
Jul 15, 2015·The Open Ophthalmology Journal·Rodrigo Bolaños-JiménezYonathan Garfias

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Investigative Ophthalmology & Visual Science
Haixia LiuTrefford Simpson
Investigative Ophthalmology & Visual Science
Alan TomlinsonAngus McFadyen
Progress in Retinal and Eye Research
B K LeungC J Radke
© 2022 Meta ULC. All rights reserved