A mass spectrometric multicenter study supports classification of preeclampsia as heterogeneous disorder

Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy
Ulrich PecksMichael O Glocker

Abstract

The diagnostic value of affinity-based matrix-assisted laser desorption/ionization time-of-flight mass spectrometry analysis to distinguish preeclampsia (PE) from matched controls was tested in a multicenter setting. Serum samples of preeclamptic (n = 60) and healthy pregnant women (n = 66) from four centers were prospectively analyzed with predefined rule sets. Overall sample classification reached sensitivity of 0.88 and specificity of 0.73. Separate calculations for early-onset PEs only (before 34 weeks of gestation) revealed sensitivity of 0.88 and specificity of 0.89. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry serum-profiling with center-wise standardization offers a fast and robust method to classify PE and contributes to the theory of PE being a heterogeneous disorder that ought to be subclassified.

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Citations

May 20, 2014·Journal of Reproductive Immunology·J C Bueno-SánchezJ G Maldonado-Estrada
May 27, 2015·International Journal of Molecular Sciences·Kai P LawPhilip N Baker
Oct 18, 2015·American Journal of Obstetrics and Gynecology·Malia S Q MurphyGraeme N Smith
May 9, 2018·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Lina A Dahabiyeh
Dec 11, 2019·Atherosclerosis. Supplements·Christine ContiniKarl Winkler

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