A matched-pair analysis comparing whole-brain radiotherapy plus stereotactic radiosurgery versus surgery plus whole-brain radiotherapy and a boost to the metastatic site for one or two brain metastases

International Journal of Radiation Oncology, Biology, Physics
Dirk RadesSteven E Schild

Abstract

To compare the results of whole-brain radiotherapy plus stereotactic radiosurgery (WBRT+SRS) with those of surgery plus whole-brain radiotherapy and a boost to the metastatic site (OP+WBRT+boost) for patients with one or two brain metastases. Survival, intracerebral control, and local control of the treated metastases were retrospectively evaluated. To reduce the risk of selection bias, a matched-pair analysis was performed. The outcomes of 47 patients who received WBRT+SRS were compared with those of a second cohort of 47 patients who recieved OP+WBRT+boost. The two treatment groups were matched for the following potential prognostic factors: WBRT schedule, age, gender, performance status, tumor type, number of brain metastases, extracerebral metastases, recursive partitioning analysis class, and interval from tumor diagnosis to WBRT. The 1-year survival rates were 65% after WBRT+SRS and 63% after OP+WBRT+boost (p = 0.19). The 1-year intracerebral control rates were 70% and 78% (p = 0.39), respectively. The 1-year local control rates were 84% and 83% (p = 0.87), respectively. On multivariate analyses, improved survival was significantly associated with better performance status (p = 0.009), no extracerebral metastases (p = 0.0...Continue Reading

References

Mar 30, 1995·International Journal of Radiation Oncology, Biology, Physics·D W Bruner, T Wasserman
Mar 1, 1997·International Journal of Radiation Oncology, Biology, Physics·L GasparR Byhardt
Mar 22, 2000·International Journal of Radiation Oncology, Biology, Physics·E WeltmanD B Wajsbrot
Apr 12, 2000·International Journal of Radiation Oncology, Biology, Physics·A TrottiW Curran
Mar 26, 2003·International Journal of Radiation Oncology, Biology, Physics·Brian Patrick O'NeillJudith R O'Fallon
Mar 10, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael A Vogelbaum, John H Suh
Mar 10, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Deepak KhuntiaMinesh P Mehta

❮ Previous
Next ❯

Citations

May 18, 2011·Radiation Oncology·Giuseppe MinnitiRiccardo Maurizi Enrici
Jun 24, 2014·Clinical Lung Cancer·David E DawePeter M Ellis
Feb 4, 2010·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Petra FeyerRolf Sauer
Feb 19, 2010·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Emmanouil FokasRita Engenhart-Cabillic
Nov 26, 2010·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Emmanouil FokasRita Engenhart-Cabillic
Jan 28, 2016·Clinical Neurology and Neurosurgery·Frederik EndersAndreas Unterberg
Jul 13, 2012·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·A L BracciniA Tallet
Aug 14, 2012·International Journal of Radiation Oncology, Biology, Physics·Julius O EbinuGelareh Zadeh
Jul 16, 2013·Clinical Neurology and Neurosurgery·Li-Jun TianZhi-Yong Yuan
Mar 1, 2010·Radiology and Oncology·Primoz Strojan
Dec 7, 2013·Expert Review of Anticancer Therapy·Hao-Wen SimMustafa Khasraw
Aug 17, 2019·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Diana SteinmannUNKNOWN Quality of Life Working Group of the German Radiation Oncology Society (DEGRO)
Jul 28, 2016·Journal of Applied Clinical Medical Physics·Eeva BomanPirkko-Liisa Kellokumpu-Lehtinen
May 12, 2009·Journal of Neuro-oncology·Michael A VogelbaumFred G Barker
Jan 5, 2021·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·A Di RitoJ Thariat
Nov 23, 2010·Lancet Neurology·Mustafa Khasraw, Jerome B Posner

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.