A mathematical framework for minimally invasive tumor ablation therapies

Critical Reviews in Biomedical Engineering
Sheldon K HallStephen Payne

Abstract

Minimally invasive tumor ablations (MITAs) are an increasingly important tool in the treatment of solid tumors across multiple organs. The problems experienced in modeling different types of MITAs are very similar, but the development of mathematical models is mostly performed in isolation according to modality. Fundamental research into the modeling of specific types of MITAs is indeed required, but to choose the optimal treatment for an individual the primary clinical requirement is to have reliable predictions for a range of MITAs. In this review of the mathematical modeling of MITAs 4 modalities are considered: radiofrequency ablation, microwave ablation, cryoablation, and irreversible electroporation. The similarities in the mathematical modeling of these treatments are highlighted, and the analysis of the models within a general framework is discussed. This will aid in developing a deeper understanding of the sensitivity of MITA models to physiological parameters and the impact of uncertainty on predictions of the ablation zone. Through robust validation and analysis of the models it will be possible to choose the best model for a given application. This is important because many different models exist with no objective c...Continue Reading

Citations

May 27, 2017·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Chang Sub ParkStephen J Payne
Mar 2, 2018·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Ean H OoiAhmad F Mohd Ali
Aug 28, 2019·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Fenggang RenYi Lv
Jun 8, 2019·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Hongjian GaoWeiwei Wu
Aug 12, 2016·Physiological Measurement·Chang Sub ParkStephen J Payne
May 23, 2015·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Sheldon K HallStephen J Payne
Sep 17, 2020·Cardiovascular and Interventional Radiology·Tim J van OostenbruggeJurgen J Fütterer
Apr 3, 2020·Electromagnetic Biology and Medicine·Sundeep Singh, Roderick Melnik
Mar 16, 2021·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Aleksandar RadosevicMacarena Trujillo

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