A mathematical model for analysis of pharmacologically induced changes in the kinetics of cardiac muscle

Journal of Pharmacological and Toxicological Methods
M W LutzT Rimele

Abstract

A mathematical model of the isometric contraction of cardiac muscle is developed and utilized to characterize the inotropic and lusitropic effects of cardioactive compounds in isolated guinea pig left atria. In contrast to metrics that are based on minima and maxima of an isometric twitch and its derivative function, the entire time course of the twitch is used to quantify the kinetics of the contraction-relaxation cycle. The model relates observed tension to a time-dependent activation function that describes generation of internal force and a coupling function that determines mechanical response to the activation function. The model is structured so that it is suitable for nonlinear curve fitting to observed data. Results obtained using the model for fitting experimental data from tissues treated with different classes of cardioactive compounds agree with more qualitative results presented by other authors. Experiments using the model to fit data over an extended (90 min) time course revealed differences in the kinetic profiles of milrinone and forskolin. Computer simulations that demonstrate the effect of each model parameter on twitch kinetics are presented, and the relationships between the model and other theoretical and ...Continue Reading

References

Nov 1, 1989·Trends in Pharmacological Sciences·A LaurenzaK B Seamon
Dec 1, 1989·Trends in Pharmacological Sciences·D J Triggle, D Rampe
Nov 1, 1987·Basic Research in Cardiology·C Mundiña de WeilenmannA Mattiazzi
May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·B Brenner
Mar 1, 1985·Journal of Molecular and Cellular Cardiology·L VittoneR A Mattiazzi
Jul 1, 1986·Journal of Molecular and Cellular Cardiology·A MattiazziH E Cingolani
Jun 14, 1972·Nature: New Biology·C C Ashley, D G Moisescu
Oct 1, 1972·Circulation Research·G H PollackP Verdugo
Jul 1, 1971·Journal of Biomechanics·Y C Fung
Mar 21, 1980·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·S Ebashi
Nov 1, 1982·Biophysical Journal·R B SteinJ Shriver
Jan 1, 1984·Annual Review of Pharmacology and Toxicology·A E FarahR P Schwarz
Aug 1, 1984·Pflügers Archiv : European journal of physiology·G CecchiG Menchetti
Dec 1, 1983·Journal of Muscle Research and Cell Motility·A S Cheung, B F Gray
Sep 1, 1994·Journal of Pharmacological and Toxicological Methods·L VittoneH Cingolani

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Citations

Mar 1, 1996·Trends in Pharmacological Sciences·R A Bond, D Girdlestone
Jul 20, 2004·BMC Pharmacology·Niels Bindslev
Aug 22, 2008·PLoS Computational Biology·Marc TurcotteElliott M Ross
Jan 16, 2007·PLoS Computational Biology·Tamara L Kinzer-Ursem, Jennifer J Linderman

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