A mathematical model for predicting drug release from a biodurable drug-eluting stent coating

Journal of Biomedical Materials Research. Part a
Syed Hossainy, Santosh Prabhu

Abstract

Drug-eluting stents (DESs) are drug-device combination products that have been commercialized and demonstrated to be safe and efficacious in treating coronary artery disease. They have been very effective in reducing the extent of neointimal hyperplasia and therefore in preventing or minimizing the occurrence of in-stent restenosis. In order to develop a successful DES, it is imperative that the coating be designed so as to deliver, after stent implantation, a therapeutic dose of the drug for the desired time duration at the site of the arterial blockage. Mathematical models are very valuable tools that can be used to study the effect of different coating parameters on drug delivery and can therefore help in coating design. We have developed a bimodal lumped-parameter mass transport model to describe the release of the drug everolimus from a biodurable fluoropolymer-based DES coating. We assume that the dispersed drug phase contributes to two discrete modes of drug transport through the coating. These are the fast mode (mode I) which is the release of the drug from a highly percolated structure of drug phase within the polymer, and the slow mode (mode II) which is the release of the drug from a nonpercolated, polymer-encapsulat...Continue Reading

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Citations

May 18, 2012·Molecular Pharmaceutics·Filippo RossiGiuseppe Perale
Feb 20, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Lothar W KleinerYunbing Wang
May 31, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Abraham R TzafririElazer R Edelman
Jan 30, 2013·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Zhiguang HuanJurek Duszczyk
Oct 15, 2011·Journal of Biomedical Materials Research. Part a·Hugh Q ZhaoLewis B Schwartz
Oct 28, 2014·Journal of Biomedical Materials Research. Part a·Xiaoxiang Zhu, Richard D Braatz
Feb 26, 2015·Acta Biomaterialia·Sean McGintyChristopher McCormick
May 6, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Anne SeidlitzWerner Weitschies
Jul 12, 2014·Mathematical Biosciences·Sean McGinty
Feb 22, 2017·Current Atherosclerosis Reports·Ankur KalraRobert W Yeh
Feb 6, 2017·Annals of Biomedical Engineering·Georgia S KaranasiouDimitrios I Fotiadis
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Oct 11, 2015·Annals of Biomedical Engineering·Paolo ZuninoFrancesco Migliavacca
Sep 16, 2016·Annals of Biomedical Engineering·Amir A Zadpoor, Jos Malda
Jun 27, 2020·Computer Methods in Biomechanics and Biomedical Engineering· SarifuddinPrashanta Kumar Mandal
Feb 9, 2018·Journal of Controlled Release : Official Journal of the Controlled Release Society·Abraham R TzafririElazer R Edelman
Oct 8, 2021·Computer Methods in Biomechanics and Biomedical Engineering·Akash Pradip Mandal, Prashanta Kumar Mandal

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