A mathematical model for selective differentiation of neural progenitor cells on micropatterned polymer substrates.

Mathematical Biosciences
Cory L HowkDonald S Sakaguchi

Abstract

The biological hypothesis that the astrocyte-secreted cytokine, interleukin-6 (IL6), stimulates differentiation of adult rat hippocampal progenitor cells (AHPCs) is considered from a mathematical perspective. The proposed mathematical model includes two different mechanisms for stimulation and is based on mass-action kinetics. Both biological mechanisms involve sequential binding, with one pathway solely utilizing surface receptors while the other pathway also involves soluble receptors. Choosing biologically-reasonable values for parameters, simulations of the mathematical model show good agreement with experimental results. A global sensitivity analysis is also conducted to determine both the most influential and non-influential parameters on cellular differentiation, providing additional insights into the biological mechanisms.

References

Jan 1, 1989·Cell and Tissue Kinetics·M LoefflerH E Wichmann
Nov 21, 1995·Proceedings of the National Academy of Sciences of the United States of America·I P Tomlinson, W F Bodmer
Jul 1, 1994·European Journal of Biochemistry·C GerhartzL Graeve
Feb 1, 1993·European Journal of Immunology·J MüllbergS Rose-John
Feb 11, 1998·Molecular Neurobiology·D L Gruol, T E Nelson
Nov 11, 1998·Nature Medicine·P S ErikssonF H Gage
Dec 14, 1999·Growth Factors·T FukadaT Hirano
Dec 20, 2000·European Journal of Biochemistry·T JostockS Rose-John
May 3, 2002·Nature·Hongjun SongFred H Gage
Mar 5, 2003·Brain, Behavior, and Immunity·Serge Rivest
Nov 15, 2003·Science·Michelle L MonjeTheo D Palmer
Sep 24, 2004·The Journal of Comparative Neurology·Bettina SeriArturo Alvarez-Buylla
Feb 22, 2005·Protein Science : a Publication of the Protein Society·Andreas SchroersJoachim Grötzinger
Mar 18, 2005·Annual Review of Immunology·Tadamitsu Kishimoto
Jun 6, 2006·Biotechnology and Bioengineering·Abhay SinghJuergen Hahn
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Matthew D JohnstonS Jonathan Chapman
Apr 5, 2007·PloS One·David DingliJorge M Pacheco
May 22, 2007·Nature Reviews. Neuroscience·Colette Dehay, Henry Kennedy
Jul 6, 2007·The European Journal of Neuroscience·Elly J F VereykenDonna L Gruol
Jun 6, 2009·Journal of Molecular Neuroscience : MN·Matthew M HarperDonald S Sakaguchi
Mar 25, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Joseph F BonnerItzhak Fischer
May 19, 2011·Nature Reviews. Neuroscience·Arjen van Ooyen
Jan 1, 2011·Computational Statistics & Data Analysis·Chonggang Xu, George Gertner

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Citations

Feb 6, 2015·Nanomedicine : Nanotechnology, Biology, and Medicine·Surya K MallapragadaHoward E Gendelman

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