PMID: 6977606Jan 1, 1981Paper

A mathematical model of B lymphocyte differentiation: control by antigen

Journal of Mathematical Biology
P KleinJ Dolezal

Abstract

A mathematical model of B lymphocyte differentiation, based on experimental results, has been developed. The model focuses on the role of antigen in initiating and regulating B cell differentiation while other mechanisms, acting in concert with antigen but the functioning of which can be circumvented under appropriate conditions, are not considered. The importance of presence of antigen at individual stages of B cell differentiation was studied in experiments with an easily metabolizable antigen. Immunocompetent cells (ICC), arising by antigen-independent differentiation of stem cells, are activated by antigen (they become immunologically activated cells--IAC). Excess of antigen drives IAC into the terminal stage (antibody-forming cells--AFC) thereby restricting proliferation. Exhaustive terminal differentiation results in tolerance. A low primary dose permits IAC to escape antigen; IAC proliferate and later give rise to resting memory cells (MC) which are amenable to reactivation. MC have higher avidity for antigen (due to higher affinity, number and density of receptors) and the effect of different doses of antigen on MC is diverse. A very low secondary dose induces tolerance, a medium dose secondary response, and the adminis...Continue Reading

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Citations

Jan 1, 1985·Folia Microbiologica·M Jílek, D Prikrylová
Nov 3, 1986·Immunology Letters·D PrikrylováJ Dolezal
Dec 21, 2012·Journal of the Royal Society, Interface·Erica ManessoCarsten Peterson
Oct 20, 2014·Journal of Pharmacokinetics and Pharmacodynamics·Timothy P HicklingSatyaprakash Nayak
Aug 22, 2016·Cellular and Molecular Life Sciences : CMLS·Klara KubelkovaAles Macela
Jan 1, 1987·Die Nahrung·J SterzlR Stĕpánková
Jan 1, 1981·Folia Microbiologica·D Vraná, J Votruba

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