PMID: 8967458May 1, 1996Paper

A mathematical model of cytosolic calcium dynamics in human umbilical vein endothelial cells

The American Journal of Physiology
T F WiesnerR M Nerem

Abstract

Important among the responses of endothelial cells are cytosolic free calcium transients. These transients are mediated by several factors, including blood-borne agonists, extracellular calcium, and fluid-imposed shear forces. The transients are characterized by a rapid rise followed by a plateau phase. A base mathematical model is presented that reasonably reproduces the measured calcium transient in cultured human umbilical vein endothelial cells responding to thrombin. Kinetic equations for receptor activation and calcium mobilization comprise the model. A graded response of intracellular free calcium to increasing concentrations of agonist is predicted. Also predicted is the elevation of the peak value and the plateau level by steady nonspecific leak of calcium across the plasma membrane. The influences of capacitative calcium entry, calcium-induced calcium release, and buffering by cytosolic proteins are investigated parametrically. The model predicts significant depletion of cellular calcium in response to agonist stimulation.

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Citations

Jan 17, 2008·Theory in Biosciences = Theorie in Den Biowissenschaften·Beate KnokeStefan Schuster
May 5, 2012·PloS One·Prashanthi VandrangiVictor G J Rodgers
Oct 11, 2017·The Journal of Physiology·Erik J BehringerSteven S Segal
Nov 3, 2010·The Journal of Chemical Physics·TaiJung ChoiShankar Subramaniam
May 12, 2009·Annals of the New York Academy of Sciences·Karthik MukundakrishnanP S Ayyaswamy
Jan 13, 2015·Biomechanics and Modeling in Mechanobiology·Long-Fei LiKai-Rong Qin
Apr 27, 2007·American Journal of Physiology. Cell Physiology·Haroldo S SilvaNikolaos M Tsoukias
Nov 10, 2010·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Nikolaos Michael Tsoukias
Dec 28, 2007·American Journal of Physiology. Cell Physiology·Dihui HongKenneth A Barbee
May 3, 2020·Journal of Clinical Medicine·Qianhui Wu, Stacey D Finley
Sep 21, 2005·Progress in Biophysics and Molecular Biology·M J PlankT David
Apr 20, 2006·Mathematical Biosciences·Jacob M KowalewskiHjalmar Brismar
May 26, 2006·The Journal of Physical Chemistry. a·Ryan FeeleyAndrew Packard

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