A mathematical model of distal nephron acidification: diuretic effects.

American Journal of Physiology. Renal Physiology
Alan M Weinstein

Abstract

Through their action on the distal nephron (DN), diuretics may produce systemic acid-base disturbances: metabolic alkalosis with thiazides or loop diuretics and metabolic acidosis with amiloride. Enhanced acid excretion may be due to a local effect on the diuretic target cell (a shift of Na+ reabsorption from NaCl transport to Na+/H+ exchange), or an effect at a distance: namely, increases in luminal fluid flow or luminal Na+ concentration may enhance more distal proton secretion. Both local and distance effects are supported by micropuncture data. In the present work, mathematical models of the distal convoluted tubule (DCT)/connecting tubule (CNT) (Weinstein AM, Am J Physiol Renal Physiol 289: F721-F741, 2005), and cortical and medullary collecting ducts (CD) (Weinstein AM, Am J Physiol Renal Physiol 283: F1237-F1251, 2002) have been concatenated to yield a model of rat DN. Among the segments of this DN, the DCT-CNT is responsible for the major portion of distal acidification. Predictions from the model calculations include the following. 1) With increasing distal Na+ delivery, there is little change in net acid excretion, but a shift in acidification locus from shared DCT and CNT contributions, to DCT prominence. 2) Urinary ...Continue Reading

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Oct 22, 2002·American Journal of Physiology. Renal Physiology·Alan M Weinstein
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Apr 28, 2005·American Journal of Physiology. Renal Physiology·Alan M Weinstein
Apr 28, 2005·American Journal of Physiology. Renal Physiology·Alan M Weinstein
Apr 28, 2006·American Journal of Physiology. Renal Physiology·Tetsuji MorimotoThomas R Kleyman
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Citations

May 19, 2009·Current Opinion in Nephrology and Hypertension·Aylin R Rodan, Chou-Long Huang
Nov 20, 2009·American Journal of Physiology. Renal Physiology·Alan M Weinstein
Nov 6, 2009·American Journal of Physiology. Renal Physiology·Aurélie Edwards
Nov 25, 2011·American Journal of Physiology. Renal Physiology·Alan M Weinstein
Oct 23, 2010·Journal of the American Society of Nephrology : JASN·Vladimir PechSusan M Wall
Jul 16, 2013·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Anita T Layton
Mar 31, 2017·American Journal of Physiology. Renal Physiology·Ying ChenAnita T Layton
Feb 26, 2010·Biodemography and Social Biology·Noreen Goldman, Jennifer B Dowd
May 3, 2013·American Journal of Physiology. Renal Physiology·Susan M Wall, Alan M Weinstein
Feb 20, 2015·American Journal of Physiology. Renal Physiology·Alan M Weinstein
Nov 16, 2012·American Journal of Physiology. Renal Physiology·Olivier Bonny, Aurélie Edwards
May 29, 2015·American Journal of Physiology. Renal Physiology·Masayoshi NanamiSusan M Wall
Oct 28, 2019·American Journal of Physiology. Renal Physiology·Aurélie Edwards, Alicia A McDonough
May 23, 2015·American Journal of Physiology. Renal Physiology·Pauline I A de BruijnJens Leipziger
Mar 17, 2020·Kidney International·Pedro Henrique Imenez SilvaCarsten Alexander Wagner
Mar 14, 2020·Journal of the American College of Cardiology·G Michael FelkerJeffrey M Testani

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