A mathematical model of haemopoiesis as exemplified by CD34 cell mobilization into the peripheral blood

Cell Proliferation
M N ObeyesekereM Korbling

Abstract

A mathematical model for the kinetics of haemopoietic cells, including CD34+cells, is proposed. This minimal model reflects the known kinetics of haemopoietic progenitor cells, including peripheral blood CD34+ cells, white blood cells and platelets, in the presence of granulocyte colony-stimulating factor. Reproducing known perturbations within this system, subjected to granulocyte colony-stimulating factor treatment and apheresis of peripheral blood progenitor cells (CD34+ cells) in healthy individuals allows validation of the model. Predictions are made with this model for reducing the length of time with neutropenia after high-dose chemotherapy. Results based on this model indicate that myelosuppressive treatment together with infusion of CD34+ peripheral blood progenitor cells favours a faster recovery of the haemopoietic system than with granulocyte colony-stimulating factor alone. Additionally, it predicts that infusion of white blood cells and platelets can relieve the symptoms of neutropenia and thrombocytopenia, respectively, without drastically hindering the haemopoietic recovery period after high dose chemotherapy.

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Citations

Apr 5, 2007·PloS One·David DingliJorge M Pacheco
Jun 3, 2014·Theoretical Biology & Medical Modelling·Sibylle SchirmMarkus Scholz
Dec 30, 2014·BMC Systems Biology·Sibylle SchirmMarkus Scholz
Jul 10, 2012·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Borislav SavkovicJohn M Murray
Jan 20, 2010·Journal of Theoretical Biology·Markus ScholzMarkus Loeffler
Jan 28, 2010·Blood·Zakary L WhichardSeth J Corey

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