A mathematical model of human semicircular canal geometry: a new basis for interpreting vestibular physiology.

Journal of the Association for Research in Otolaryngology : JARO
Andrew P BradshawG M Halmagyi

Abstract

We report a precise, simple, and accessible method of mathematically measuring and modeling the three-dimensional (3D) geometry of semicircular canals (SCCs) in living humans. Knowledge of this geometry helps understand the development and physiology of SCC stimulation. We developed a framework of robust techniques that automatically and accurately reconstruct SCC geometry from computed tomography (CT) images and are directly validated using micro-CT as ground truth. This framework measures the 3D centroid paths of the bony SCCs allowing direct comparison and analysis between ears within and between subjects. An average set of SCC morphology is calculated from 34 human ears, within which other geometrical attributes such as nonplanarity, radius of curvature, and inter-SCC angle are examined, with a focus on physiological implications. These measurements have also been used to critically evaluate plane fitting techniques that reconcile many of the discrepancies in current SCC plane studies. Finally, we mathematically model SCC geometry using Fourier series equations. This work has the potential to reinterpret physiology and pathophysiology in terms of real individual 3D morphology.

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Citations

Feb 3, 2011·Experimental Brain Research·Brian L DayRichard C Fitzpatrick
Jun 2, 2011·Journal of the Association for Research in Otolaryngology : JARO·Swee Tin AwGabor Michael Halmagyi
May 30, 2013·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Hamish G MacDougallKonrad P Weber
May 1, 2013·PloS One·Hamish Gavin MacdougallKonrad Peter Weber
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Sep 21, 2013·IEEE Transactions on Image Processing : a Publication of the IEEE Signal Processing Society·Andrew Philip BradshawG Michael Halmagyi
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Oct 4, 2016·Frontiers in Neurology·Dominik ObristMichael Strupp
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Dec 24, 2019·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·BoYoon ChoiChang-Hee Kim
Apr 30, 2020·PloS One·Patrick M CarryNancy Hadley Miller
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Mar 15, 2018·Frontiers in Neuroscience·Lejo Johnson ChackoAnneliese Schrott-Fischer
Jan 23, 2014·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Béla Büki
Jun 27, 2017·Frontiers in Neurology·G M HalmagyiIan S Curthoys
Mar 2, 2021·Journal of Vestibular Research : Equilibrium & Orientation·Chiheon KwonHee Chan Kim
Jan 26, 2021·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Matthew MorozManohar Bance
May 23, 2021·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Christopher M SmithJeffrey T Laitman
Aug 3, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Anita BhandariMichael Strupp
Oct 12, 2021·Frontiers in Neurology·Shuzhi WuXiaokai Yang

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