PMID: 11604091Oct 18, 2001Paper

A mathematical model of radiation carcinogenesis with induction of genomic instability and cell death

Radiation Research
M Ohtaki, O Niwa

Abstract

We developed a mathematical model of carcinogenesis that incorporates genomic instability, a feature characterized by long-term destabilization of the genome in irradiated cells that leads to an increase in cancer risk in the exposed individuals at the cancer-prone age. This model also considers the induction of cell death, another important effect of radiation on cells. It is assumed that cell killing by radiation may occur at all stages of the carcinogenic process. The resulting model can explain not only the paradoxical relationship between low mutation rates and high cancer incidence but also the low-order dose-response relationship of cancer risk.

References

Dec 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·A R KennedyJ B Little
Feb 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·K KamiyaK H Clifton
May 1, 1997·International Journal of Radiation Biology·M MatsuuraF Kasagi
Mar 1, 1954·British Journal of Cancer·P ARMITAGE, R DOLL

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Citations

Nov 30, 2010·Radiation Protection Dosimetry·I ShuryakD J Brenner
Feb 22, 2011·American Journal of Epidemiology·Mihoko DoiNobuoki Kohno
Dec 31, 2010·Dose-response : a Publication of International Hormesis Society·Yuchao Zhao, Paolo F Ricci
Sep 3, 2005·Radiation Research·Rainer K SachsPhilip Hahnfeldt

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