A mathematical model of rat ascending Henle limb. III. Tubular function.

American Journal of Physiology. Renal Physiology
Alan M Weinstein

Abstract

K+ plays a catalytic role in AHL Na+ reabsorption via Na+-K+-2Cl- cotransporter (NKCC2), recycling across luminal K+ channels, so that luminal K+ is not depleted. Based on models of the ascending Henle limb (AHL) epithelium, it has been hypothesized that NH4+ may also catalyze luminal Na+ uptake. This hypothesis requires that luminal NH4+ not be depleted, implying replenishment via either direct secretion of NH4+, or NH3 in parallel with a proton. In the present work, epithelial models of rat medullary and cortical AHL (Weinstein AM, Krahn TA. Am J Physiol Renal Physiol 298: F000-F000, 2009) are configured as tubules and examined in simulations of function in vitro and in vivo to assess the feasibility of a catalytic role for NH4+ in Na+ reabsorption. Modulation of Na+ transport is also examined by peritubular K+ concentration and by Bartter-type transport defects in NKCC2 (type 1), in luminal membrane K+ channels (type 2), and in peritubular Cl- channels (type 3). It is found that a catalytic role for NH4+, which is significant in magnitude (relative to K+), is quantitatively realistic, in terms of uptake via NKCC2, and in terms of luminal membrane ammonia backflux. Simulation of a 90% NKCC2 defect is predicted to double dista...Continue Reading

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Nov 20, 2009·American Journal of Physiology. Renal Physiology·Alan M Weinstein

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Citations

Jun 7, 2012·Interface Focus·David P NickersonPeter J Hunter
Nov 20, 2009·American Journal of Physiology. Renal Physiology·Alan M Weinstein, Thomas A Krahn
Nov 25, 2011·American Journal of Physiology. Renal Physiology·Alan M Weinstein
Mar 26, 2010·American Journal of Physiology. Renal Physiology·Jing ChenAnita T Layton
Dec 17, 2009·American Journal of Physiology. Renal Physiology·Aurélie Edwards
Mar 24, 2016·Nature·M DellingD E Clapham
Oct 24, 2014·Frontiers in Physiology·Gabriel StöltingChristoph Fahlke
Aug 19, 2015·PloS One·Lorette NoiretS Randall Thomas
Feb 10, 2017·American Journal of Physiology. Renal Physiology·Alan M Weinstein
May 31, 2018·American Journal of Physiology. Renal Physiology·Qianyi LiAnita T Layton
Jul 16, 2013·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Anita T Layton
Oct 11, 2013·American Journal of Physiology. Renal Physiology·Robert Moss, S Randall Thomas
Jan 31, 2014·American Journal of Physiology. Renal Physiology·Liangjian Lu, James A Fraser
Mar 22, 2014·American Journal of Physiology. Renal Physiology·I David Weiner, Jill W Verlander
Feb 20, 2015·American Journal of Physiology. Renal Physiology·Alan M Weinstein
Feb 27, 2015·American Journal of Physiology. Renal Physiology·Anita T Layton
May 23, 2014·American Journal of Physiology. Renal Physiology·Aurélie EdwardsAnita T Layton
Jan 20, 2017·American Journal of Physiology. Renal Physiology·Anita T Layton
Feb 25, 2020·American Journal of Physiology. Renal Physiology·Alan M Weinstein
Dec 19, 2014·American Journal of Physiology. Renal Physiology·Aurélie Edwards
Oct 26, 2012·American Journal of Physiology. Renal Physiology·Aniel Nieves-GonzálezLeon C Moore
Jul 6, 2020·Pflügers Archiv : European journal of physiology·Dong Hoon ShinMin Goo Lee
Oct 26, 2012·American Journal of Physiology. Renal Physiology·Aniel Nieves-GonzálezLeon C Moore
Mar 14, 2020·Genes·Caroline Prot-Bertoye, Pascal Houillier
Nov 15, 2019·Morphologie : Bulletin De L'Association Des Anatomistes·S Randall Thomas

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