Abstract
K+ plays a catalytic role in AHL Na+ reabsorption via Na+-K+-2Cl- cotransporter (NKCC2), recycling across luminal K+ channels, so that luminal K+ is not depleted. Based on models of the ascending Henle limb (AHL) epithelium, it has been hypothesized that NH4+ may also catalyze luminal Na+ uptake. This hypothesis requires that luminal NH4+ not be depleted, implying replenishment via either direct secretion of NH4+, or NH3 in parallel with a proton. In the present work, epithelial models of rat medullary and cortical AHL (Weinstein AM, Krahn TA. Am J Physiol Renal Physiol 298: F000-F000, 2009) are configured as tubules and examined in simulations of function in vitro and in vivo to assess the feasibility of a catalytic role for NH4+ in Na+ reabsorption. Modulation of Na+ transport is also examined by peritubular K+ concentration and by Bartter-type transport defects in NKCC2 (type 1), in luminal membrane K+ channels (type 2), and in peritubular Cl- channels (type 3). It is found that a catalytic role for NH4+, which is significant in magnitude (relative to K+), is quantitatively realistic, in terms of uptake via NKCC2, and in terms of luminal membrane ammonia backflux. Simulation of a 90% NKCC2 defect is predicted to double dista...Continue Reading
References
Jan 1, 1979·The Journal of Clinical Investigation·D Z LevineS Raman
Mar 1, 1992·The Journal of General Physiology·D KikeriS C Hebert
Feb 1, 1991·Pflügers Archiv : European journal of physiology·K KunzelmannR Greger
Aug 1, 1991·The Journal of Clinical Investigation·G CapassoG Giebisch
Apr 26, 1991·Biochimica Et Biophysica Acta·P L Fernandes, H G Ferreira
May 11, 1991·The American Journal of Physiology·T D DuBose, D W Good
Mar 1, 1990·The American Journal of Physiology·D KikeriS C Hebert
Jul 1, 1988·The American Journal of Physiology·D W Good
Jan 1, 1986·The Journal of Membrane Biology·R KinneB Schölermann
Aug 1, 1987·The American Journal of Physiology·J L Garvin, M A Knepper
Sep 1, 1985·Kidney International·M HropotG Giebisch
Aug 1, 1982·The Journal of Clinical Investigation·J B Stokes
Sep 1, 1984·The American Journal of Physiology·C S WilcoxG Giebisch
Nov 1, 1983·The American Journal of Physiology·P JaegerG Giebisch
Jul 1, 1984·The American Journal of Physiology·D W GoodM B Burg
Jul 1, 1982·The Journal of Clinical Investigation·J BuerkertD Trigg
Sep 9, 1982·Nature·P S AronsonM A Suhm
Oct 1, 1994·Kidney International·R UnwinG Giebisch
Jan 1, 1994·Annual Review of Physiology·D W Good
May 1, 1994·The Journal of General Physiology·B A Watts, D W Good
Jun 5, 1998·The American Journal of Physiology·A M Weinstein
Jul 15, 2000·American Journal of Physiology. Renal Physiology·A M Weinstein
Jul 25, 2000·Journal of the American Society of Nephrology : JASN·Martin KonradFriedhelm Hildebrandt
Oct 22, 2002·American Journal of Physiology. Renal Physiology·Alan M Weinstein
Aug 2, 2003·American Journal of Physiology. Renal Physiology·Tong WangWen-Hui Wang
Apr 28, 2005·American Journal of Physiology. Renal Physiology·Alan M Weinstein
Sep 28, 2006·Annual Review of Physiology·I David Weiner, L Lee Hamm
Jan 4, 2007·American Journal of Physiology. Renal Physiology·Gustavo FrindtLawrence G Palmer
Aug 22, 2008·American Journal of Physiology. Renal Physiology·Alan M Weinstein
Nov 20, 2009·American Journal of Physiology. Renal Physiology·Alan M Weinstein, Thomas A Krahn
Nov 20, 2009·American Journal of Physiology. Renal Physiology·Alan M Weinstein
Citations
Jun 7, 2012·Interface Focus·David P NickersonPeter J Hunter
Nov 20, 2009·American Journal of Physiology. Renal Physiology·Alan M Weinstein, Thomas A Krahn
Nov 25, 2011·American Journal of Physiology. Renal Physiology·Alan M Weinstein
Mar 26, 2010·American Journal of Physiology. Renal Physiology·Jing ChenAnita T Layton
Dec 17, 2009·American Journal of Physiology. Renal Physiology·Aurélie Edwards
Jan 19, 2016·Frontiers in Physiology·Kouhei SasamotoYoshinori Marunaka
Mar 24, 2016·Nature·M DellingD E Clapham
Oct 24, 2014·Frontiers in Physiology·Gabriel StöltingChristoph Fahlke
Aug 19, 2015·PloS One·Lorette NoiretS Randall Thomas
Jun 9, 2016·PloS One·Sagari SarkarDeclan G M Murphy
Feb 10, 2017·American Journal of Physiology. Renal Physiology·Alan M Weinstein
May 31, 2018·American Journal of Physiology. Renal Physiology·Qianyi LiAnita T Layton
Jul 16, 2013·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Anita T Layton
Oct 11, 2013·American Journal of Physiology. Renal Physiology·Robert Moss, S Randall Thomas
Jan 31, 2014·American Journal of Physiology. Renal Physiology·Liangjian Lu, James A Fraser
Mar 22, 2014·American Journal of Physiology. Renal Physiology·I David Weiner, Jill W Verlander
Feb 20, 2015·American Journal of Physiology. Renal Physiology·Alan M Weinstein
Feb 27, 2015·American Journal of Physiology. Renal Physiology·Anita T Layton
May 23, 2014·American Journal of Physiology. Renal Physiology·Aurélie EdwardsAnita T Layton
Jan 20, 2017·American Journal of Physiology. Renal Physiology·Anita T Layton
Feb 25, 2020·American Journal of Physiology. Renal Physiology·Alan M Weinstein
Aug 18, 2020·PLoS Computational Biology·Hongtao YuK Melissa Hallow
Dec 19, 2014·American Journal of Physiology. Renal Physiology·Aurélie Edwards
Oct 26, 2012·American Journal of Physiology. Renal Physiology·Aniel Nieves-GonzálezLeon C Moore
Jul 6, 2020·Pflügers Archiv : European journal of physiology·Dong Hoon ShinMin Goo Lee
Oct 26, 2012·American Journal of Physiology. Renal Physiology·Aniel Nieves-GonzálezLeon C Moore
Mar 14, 2020·Genes·Caroline Prot-Bertoye, Pascal Houillier
Nov 15, 2019·Morphologie : Bulletin De L'Association Des Anatomistes·S Randall Thomas