A mathematical model of rat ascending Henle limb. I. Cotransporter function.

American Journal of Physiology. Renal Physiology
A M Weinstein

Abstract

Kinetic models of Na+-K+-2Cl- costransporter (NKCC2) and K+-Cl- cotransporter (KCC4), two of the key cotransporters of the Henle limb, are fashioned with inclusion of terms representing binding and transport of NH4+. The models are simplified using assumptions of equilibrium ion binding, binding symmetry, and identity of Cl- binding sites. Model parameters are selected to be consistent with flux data from expression of these transporters in oocytes, specifically inwardly directed coupled transport of rubidium. In the analysis of these models, it is found that despite the simplifying assumptions to reduce the number of model parameters, neither model is uniquely determined by the data. For NKCC or KCC there are two- or three-parameter families of "optimal" solutions. As a consequence, one may specify several carrier translocation rates and/or ion affinities before fitting the remaining coefficients to the data, with no loss of fidelity in simulating the experiments. Model calculations suggest that with respect to NKCC2 near its operating point, the curve of ion flux as a function of cell Cl- is steep, and with respect to KCC4, its curve of ion flux as a function of peritubular K+ is also steep. The implication is that the kineti...Continue Reading

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Nov 28, 2008·American Journal of Physiology. Renal Physiology·Mariano MarcanoLeon C Moore

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Citations

Jun 7, 2012·Interface Focus·David P NickersonPeter J Hunter
Jan 7, 2011·American Journal of Physiology. Cell Physiology·Marina FericMark A Knepper
Nov 20, 2009·American Journal of Physiology. Renal Physiology·Alan M Weinstein, Thomas A Krahn
Nov 20, 2009·American Journal of Physiology. Renal Physiology·Alan M Weinstein
Dec 17, 2009·American Journal of Physiology. Renal Physiology·Aurélie Edwards
Oct 29, 2015·The Journal of Physiological Sciences : JPS·Shingo Murakami, Yoshihisa Kurachi
Nov 16, 2010·The Biochemical Journal·Anie AzroyanAurélie Edwards
Jul 15, 2016·The Journal of Physiology·Luciana MorlaAurélie Edwards
Aug 16, 2017·Proceedings of the National Academy of Sciences of the United States of America·Conner I SandefurTimothy C Elston
Jul 16, 2013·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Anita T Layton
Oct 11, 2013·American Journal of Physiology. Renal Physiology·Robert Moss, S Randall Thomas
Nov 8, 2013·American Journal of Physiology. Renal Physiology·Branko Braam
Jan 31, 2014·American Journal of Physiology. Renal Physiology·Liangjian Lu, James A Fraser
Jun 26, 2015·American Journal of Physiology. Renal Physiology·Mónica Nadal-QuirósMariano Marcano
Nov 16, 2012·American Journal of Physiology. Renal Physiology·Olivier Bonny, Aurélie Edwards
Apr 22, 2016·American Journal of Physiology. Renal Physiology·Silvana Bazúa-ValentiGerardo Gamba
Jul 22, 2011·American Journal of Physiology. Cell Physiology·Eric Delpire, Kenneth B Gagnon
Oct 26, 2012·American Journal of Physiology. Renal Physiology·Aniel Nieves-GonzálezLeon C Moore
Mar 30, 2021·American Journal of Physiology. Renal Physiology·Alan M Weinstein

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