PMID: 3753090Jul 1, 1986Paper

A mathematical model of survival kinetics. II. Parameter estimation

Archives of Gerontology and Geriatrics
L PiantanelliG Linari

Abstract

Procedures for the estimation of the four parameters of a new mathematical model of survival and mortality kinetics are given. A formulation of the model has been found which had the advantage of maintaining three of four parameters independent of the unit chosen for the age; in addition, two of these parameters have values falling in a narrow range, even when the model is applied to rather different curves. Since, in any problem of this type, the initial estimate of the parameters plays a major role in the achievement of good final estimates, some simple methods of estimation are indicated based upon the characteristics of the function. The initial estimates may enter three different types of procedures; the best one can be chosen according to the precision of the initial estimates. The method is capable of fitting both survivorship and dying functions directly to the empirical data. An interactive approach to the computer facilities has been used as at each step the operator has to decide whether or not to apply a corrective factor. Goodness of fit, usually high, is estimated by chi 2 test.

References

Jul 1, 1986·Archives of Gerontology and Geriatrics·L Piantanelli
Jan 1, 1970·Gerontologia·D Schlettwein-Gsell

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Citations

Mar 1, 1988·Mechanisms of Ageing and Development·W Slob, C Janse
Jan 1, 1990·Mechanisms of Ageing and Development·P J Neafsey
Jul 1, 1986·Archives of Gerontology and Geriatrics·L Piantanelli
Dec 1, 1986·Archives of Gerontology and Geriatrics·L PiantanelliA Basso
Sep 22, 2010·Neurobiology of Aging·Norbert SchuffUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jan 1, 1988·Drug Metabolism Reviews·H BoxenbaumD J Fournier

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