A mathematical model of the Gac/Rsm quorum sensing network in Pseudomonas fluorescens

Bio Systems
David Brown

Abstract

I present a deterministic model of the dynamics of signal transduction and gene expression in the Gac/Rsm network of the soil-dwelling bacterium Pseudomonas fluorescens. The network is involved in quorum sensing and governs antifungal production in this important biocontrol agent. A central role is played by small untranslated RNAs, which sequester regulatory mRNA-binding proteins. The model provides a reasonable match to the available data, which consists primarily of time series from reporter gene fusions. I use the model to investigate the information-processing properties of the Gac/Rsm network, in part by comparing it to a simplified model capable of quorum sensing. The results suggest that the complexity and redundancy of the Gac/Rsm network have evolved to meet the conflicting requirements of high sensitivity to environmental conditions and a conservative, robust response to variability in parameter values. Similar systems exist in a wide variety of bacteria, where they control a diverse set of population-dependent behaviors. This makes them important subjects for mathematical models that can help link empirical understanding of network structure to theoretical insights into how these networks have evolved to function un...Continue Reading

References

Jan 9, 2001·Bulletin of Mathematical Biology·J D Dockery, J P Keener
Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·S M BlowerJ Mills
Jan 5, 2002·Molecular Plant-microbe Interactions : MPMI·S Heeb, D Haas
Aug 6, 2002·Trends in Microbiology·Rosemary J Redfield
Oct 30, 2003·Omics : a Journal of Integrative Biology·Chris D CoxMichael L Simpson
Nov 11, 2003·Bulletin of Mathematical Biology·D L ChoppM R Parsek
Sep 20, 2005·PLoS Computational Biology·Andrew B GoryachevLian-Hui Zhang
Nov 16, 2005·Proceedings of the National Academy of Sciences of the United States of America·Elisabeth KayDieter Haas
Dec 20, 2005·Journal of Molecular Biology·Stephan HeebPaul Williams
Jun 6, 2006·Journal of Theoretical Biology·Bradford E PeercyGeorge Bennett
Jan 24, 2007·Journal of Theoretical Biology·Dawei HongJoseph V Martin
Feb 17, 2007·Nature Reviews. Microbiology·Burkhard A HenseJan-Ulrich Kreft
Mar 28, 2007·Current Opinion in Microbiology·Michal Bejerano-Sagie, Karina Bivar Xavier
Aug 21, 2007·Nature Structural & Molecular Biology·Mario SchubertFrédéric H-T Allain
Oct 10, 2007·PLoS Computational Biology·Ryan N GutenkunstJames P Sethna
Jan 1, 2008·Journal of Theoretical Biology·Christina Kuttler, Burkhard A Hense
Feb 19, 2008·Bio Systems·Johannes MüllerBurkhard A Hense
Sep 5, 2008·PLoS Computational Biology·Yu TanouchiLingchong You
Oct 29, 2008·Biotechnology Journal·David Brown, C Phoebe Lostroh
Dec 20, 2008·Molecular Systems Biology·Joshua W WilliamsAnn M Stevens
Aug 19, 2009·Annual Review of Genetics·Wai-Leung Ng, Bonnie L Bassler

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Citations

May 25, 2011·Applied Microbiology and Biotechnology·Elisabeth Sonnleitner, Dieter Haas
Jul 31, 2013·Bulletin of Mathematical Biology·David Brown
Oct 12, 2013·Nature Communications·Alexandre JoussetStefan Scheu
Aug 27, 2016·Bulletin of Mathematical Biology·Judith Pérez-VelázquezRodolfo García-Contreras
Aug 17, 2014·Applied and Environmental Microbiology·Daiming ZhaYunjun Yan
May 4, 2021·Environmental Microbiology·María-Dolores Ferreiro, María-Trinidad Gallegos
Dec 24, 2010·Chemical Reviews·Andrew B Goryachev

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