PMID: 6406766Apr 1, 1983Paper

A mathematical model of the human respiratory system

Journal of Biomedical Engineering
W F Fincham, F T Tehrani

Abstract

A model of the human respiratory system is proposed which has a satisfactory performance under different physiological conditions. The model comprises a continuous plant and a discrete controller which generates and updates the drive signal to the plant at the end of every breath to represent the Hering-Breuer reflex. Arterial and central medullary sensors are included. The lung volume, dead space volume, cardiac output and cerebral blood flow are time varying. The respiratory work is minimized. The model is examined and simulation results of its performance in hypercapnia, hypoxia, periodic breathing and moderate exercise are presented. The responses presented include the relatively fast transients of Cheyne-Stokes breathing and the slower transients associated with carbon dioxide inhalation.

References

Jan 1, 1983·Journal of Biomedical Engineering·W Fincham, F T Tehrani
Nov 1, 1960·Anesthesiology·C J LAMBERTSEN
Oct 1, 1960·Physics in Medicine and Biology·B F VISSER
Jan 1, 1965·Biophysical Journal·H T MILHORNA C GUYTON
Jun 15, 1909·The Journal of Physiology·C G Douglas, J S Haldane

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Citations

Jan 1, 1992·Annals of Biomedical Engineering·F T Tehrani
Nov 4, 2000·Computers in Biology and Medicine·A Qiu, J Bai
Apr 26, 2012·Journal of Clinical Monitoring and Computing·Fleur T Tehrani, Soraya Abbasi
Dec 6, 2011·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Alona Ben-Tal
Mar 5, 2014·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Alona Ben-Tal, Merryn H Tawhai
Jul 1, 1994·Medical Engineering & Physics·F T Tehrani, A R Bazar
Feb 21, 2013·Computer Methods and Programs in Biomedicine·Fleur T Tehrani
May 1, 1993·IEEE Transactions on Bio-medical Engineering·F T Tehrani
Sep 26, 2003·Physiological Measurement·C J EvansP R F Dear
Oct 14, 2004·Journal of Mathematical Biology·Jerry J BatzelSusanne Timischl-Teschl
Oct 1, 1992·Pediatric Pulmonology·V K BhutaniM Delivoria-Papadopoulos
Feb 23, 2020·Healthcare Technology Letters·Fleur T Tehrani
Feb 23, 2018·Frontiers in Physiology·Leidy Y SernaRoberto A Rabinovich
Jan 9, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Carlos Andrés SarmientoMiguel Ángel Mañanas

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