A mathematical model of the interaction between bovine blastocyst developmental stage and progesterone-stimulated uterine factors on differential embryonic development observed on Day 15 of gestation.

Journal of Dairy Science
Paul R ShortenDebra K Berg

Abstract

A complex interaction between the developing bovine embryo and the growth potential of the uterine milieu it inhabits results in an embryo capable of developing past the maternal recognition stage and on to a successful pregnancy. Previously, we observed variation in the lengths of embryos recovered 8 d after bulk transfer of Day 7 in vitro-produced (IVP) blastocysts into the same uterus. Potential causes of the differential embryonic growth were examined and modeled using 2 rounds of bulk (n = 4-6) IVP transfers and recovery of these embryos 8 d later. Morphological and gene expression measurements of the embryos were determined and the progesterone concentration of the cows was measured throughout the reproductive cycle as a reflection of the status of the uterine environment. These data were used to develop and evaluate a model that describes the interaction between the uterine environment and the growth rate of the developing embryo. Expression of 6 trophectoderm genes (IFNT, TKDP1, PAG11, PTGS2, DKK1, and PDPN) was correlated with conceptus length. The model determined that if the embryo develops to blastocyst stage, the uterine environment, driven by progesterone, is a more important component than blastocyst size in the ...Continue Reading

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Citations

Feb 13, 2018·Proceedings of the National Academy of Sciences of the United States of America·Joao G N MoraesThomas E Spencer
Jul 6, 2020·Journal of Dairy Science·P Lonergan, J M Sánchez
Jun 11, 2019·Biology of Reproduction·Constantine A SimintirasPatrick Lonergan
Aug 13, 2020·Animals : an Open Access Journal From MDPI·Jordana S LopesPilar Coy
Jun 25, 2018·Journal of Dairy Science·P R ShortenD Berg

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