A Mathematical Model Relating Pitocin Use during Labor with Offspring Autism Development in terms of Oxytocin Receptor Desensitization in the Fetal Brain

Computational and Mathematical Methods in Medicine
Mark M Gottlieb

Abstract

This paper develops a mathematical model describing the potential buildup of high oxytocin concentrations in the maternal circulation during labor in terms of continuous Pitocin infusion rate, half-life, and maternal weight. Oxytocin override of the degradation of oxytocin by placental oxytocinase is introduced to model the potential transfer of oxytocin from the maternal circulation across the placenta into the fetal circulation and from there into the brain of the fetus. The desensitization unit D equal to 1.8E6 (pg·min)/ml is employed to establish a desensitization threshold and by extension, a downregulation threshold as a function of oxytocin override concentration and continuous Pitocin infusion time, that could be a factor in the subsequent development of autism among offspring. Epidemiological studies by Duke University [1], Yale University [2], and Harvard University [3] are discussed regarding Pitocin use and offspring autism development for an explanation of the weak correlations they identified. The findings of the Harvard epidemiological study are reinterpreted regarding Pitocin use and its conclusion questioned. Further evaluations of the findings of these three epidemiological studies are called for to incorporat...Continue Reading

References

Apr 1, 1989·American Journal of Perinatology·T Chard
Jan 1, 1988·Journal of Perinatal Medicine·R R OdemM Y Dawood
Jan 1, 1974·Gynecologic Investigation·M OyaT Wakabayashi
Jul 1, 1983·Canadian Journal of Biochemistry and Cell Biology = Revue Canadienne De Biochimie Et Biologie Cellulaire·M S SoloffM Wieder
Jun 1, 1981·European Journal of Obstetrics, Gynecology, and Reproductive Biology·M Y Dawood, F Fuchs
Feb 1, 1994·American Journal of Obstetrics and Gynecology·R J WillcourtR W Hale
Dec 28, 1999·British Journal of Obstetrics and Gynaecology·C PatientS Thornton
Feb 20, 2003·American Journal of Obstetrics and Gynecology·Christopher RobinsonRoger C Young
Jul 8, 1961·Nature·S E MELANDER
Oct 23, 2009·BMC Medicine·Simon G GregoryMargaret A Pericak-Vance
Dec 31, 2011·American Journal of Obstetrics and Gynecology·Rachel M TribePhilip N Baker
Apr 6, 2012·Frontiers in Pharmacology·Norman R SaundersKatarzyna M Dziegielewska
May 10, 2012·Obstetrics and Gynecology·Lorie M HarperAlison G Cahill
Jan 30, 2014·Journal of Midwifery & Women's Health·Aleeca F BellC Sue Carter
Jan 31, 2014·Frontiers in Public Health·Marie PrevostIan Gold
Aug 6, 2014·Proceedings of the National Academy of Sciences of the United States of America·Karen J ParkerAntonio Y Hardan
Feb 25, 2015·Behavioural Brain Research·Omri WeismanSøren Dalsgaard
Nov 8, 2015·Behavioural Brain Research·Mark M Gottlieb
Jul 28, 2016·JAMA Pediatrics·Anna Sara ObergBrian T Bateman
Apr 8, 2018·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Jiuying LiuXu Weiwei

❮ Previous
Next ❯

Citations

Dec 13, 2019·Computational and Mathematical Methods in Medicine·Mark M Gottlieb
Nov 17, 2021·Pediatric Obesity·Arvind PalanisamyNicole N Lønfeldt

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autism

Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research on autism.

Related Papers

Nederlands tijdschrift voor geneeskunde
K BULTERIJS
Journal of the Medical Association of the State of Alabama
J C WELBURNO T WEST
The American Journal of Psychiatry
D FeinL Waterhouse
© 2021 Meta ULC. All rights reserved