A Matrix-based Model Predicts Primary Response to Infliximab in Crohn's Disease

Journal of Crohn's & Colitis
Thomas BillietSeverine Vermeire

Abstract

Prediction of primary non-response [PNR] to anti-tumour necrosis factors [TNFs] in inflammatory bowel disease [IBD] is direly needed to select the optimal therapeutic class for a given patient. We developed a matrix-based prediction tool to predict response to infliximab [IFX] in Crohn's disease [CD] patients. This retrospective single-centre study included 201 anti-TNF naïve CD patients who started with IFX induction therapy. PNR occurred in 16 [8%] patients. Clinical, biological [including serum TNF and the IBD serology 6 panel and genetic [the 163 validated IBD risk loci] markers were collected before start. Based on the best fitted regression model, probabilities of primary response to IFX were calculated and arranged in a prediction matrix tool. Multiple logistic regression withheld three final independent predictors [p < 0.05] for PNR: age at first IFX, {odds ratio (OR) (95% confidence interval [CI] of 1.1 (1.0-1.1)}, body mass index [BMI] (0.86 [0.7-1.0]), and previous surgery (4.4 [1.2-16.5]). The accuracy of this prediction model did not improve when the genetic markers were added (area under the curve [AUC] from 0.80 [0.67-0.93] to 0.78 [0.65-0.91]). The predicted probabilities for PNR to IFX increased from 1% to 53% ...Continue Reading

References

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Citations

Mar 20, 2016·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·María Del Carmen R-GrauJavier P Gisbert
Jun 23, 2016·Expert Opinion on Biological Therapy·Lieven PouillonLaurent Peyrin-Biroulet
Jan 10, 2018·Alimentary Pharmacology & Therapeutics·D Sawbridge, S Subramanian
Nov 11, 2017·Alimentary Pharmacology & Therapeutics·H Bar-YosephB Ungar
Feb 28, 2018·Clinical & Translational Immunology·Bram VerstocktJames C Lee
Mar 14, 2019·Current Pharmaceutical Design·Christopher R Lindholm, Corey A Siegel
Apr 7, 2020·European Journal of Gastroenterology & Hepatology·María ChaparroUNKNOWN PREDICROHN Study Group from GETECCU
Jun 25, 2020·International Journal of Colorectal Disease·Lijun XuQing Zheng
Apr 8, 2020·Scandinavian Journal of Gastroenterology·Vendel A KristensenMorten H Vatn
Sep 29, 2020·Frontiers in Medicine·Raja AtreyaBritta Siegmund
Oct 8, 2019·Expert Opinion on Therapeutic Targets·Sare VerstocktSéverine Vermeire
Dec 11, 2019·The Lancet. Gastroenterology & Hepatology·Nurulamin M NoorJames C Lee
Nov 11, 2017·Gastroenterology·Parambir S DulaiWilliam J Sandborn
Mar 18, 2021·Journal of Crohn's & Colitis·Bram VerstocktUNKNOWN Scientific Workshop Steering Committee

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