A matter of access. Nucleosome disassembly from gene promoters is the central goal of transcriptional activators

Transcription
Zheng HuJessica K Tyler

Abstract

The mechanism whereby transcriptional activators facilitate transcription activation has been debated. Our recent genome-wide profiling of gene expression during aging, where nucleosomes are depleted, indicates that the function of seemingly all transcriptional activators is to trigger nucleosome disassembly from promoters to allow the general transcription machinery access to the DNA.

References

Apr 10, 1997·Nature·M Ptashne, A Gann
Jun 25, 2003·Molecular Cell·Hinrich BoegerRoger D Kornberg
Sep 14, 2010·Molecular Cell·Jason FeserJessica K Tyler
Aug 6, 2013·Cell·Geeta J NarlikarTom Owen-Hughes
Nov 28, 2013·Biochimica Et Biophysica Acta·Ferenc Müller, Làszlò Tora
Apr 12, 2014·PLoS Genetics·Hesheng ZhangDavid S Gross

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