A Matter of Controversy: Is Radioiodine Therapy Favorable in Differentiated Thyroid Carcinoma?

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Matthias SchmidtMarkus Dietlein

Abstract

Radioiodine therapy is a matter of controversy because different opinions exist about its use for differentiated thyroid carcinoma. The following article sheds light on the different opinions and explains why we advocate the use of radioiodine therapy in more than only high-risk patients. In comparison to other malignancies, differentiated thyroid carcinoma has a different tumor biology due to its usually slow growth pattern. Radioiodine therapy was first used about 75 y ago and provided cure at a time when prospective randomized controlled trials had yet to be developed. Large patient cohorts and usually at least a decade of clinical follow-up are needed to demonstrate a benefit from radioiodine therapy. Thus, especially in low-risk patients, many factors define an individual treatment decision, including tumor stage, extent of surgery, tumor biology, clinical and imaging data, life expectancy, and patient preferences.

References

Oct 30, 2003·British Journal of Cancer·C RubinoM Schlumberger
Jun 10, 2005·The New England Journal of Medicine·Trisha M ShattuckAndrew Arnold
Nov 22, 2007·The Journal of Clinical Endocrinology and Metabolism·Aaron P BrownJonathan D Tward
Aug 21, 2008·European Journal of Endocrinology·Elio RotiLewis E Braverman
Sep 10, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Eun-Kyung ParkBo Youn Cho
Mar 31, 2010·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Barbara E Hertz, Kristin E Schuller
Feb 9, 2012·Thyroid : Official Journal of the American Thyroid Association·Tobias CarlingUNKNOWN American Thyroid Association Surgical Affairs Committee
Feb 10, 2012·Clinical Oncology : a Journal of the Royal College of Radiologists·U MallickUNKNOWN IoN Trial Management Group
May 4, 2012·The New England Journal of Medicine·Martin SchlumbergerUNKNOWN Tumeurs de la Thyroïde Refractaires Network for the Essai Stimulation Ablation Equivalence Trial
May 4, 2012·The New England Journal of Medicine·Ujjal MallickAllan Hackshaw
Mar 5, 2013·Langenbeck's Archives of Surgery·Henning DralleUNKNOWN German Societies of General and Visceral Surgery; Endocrinology; Nuclear Medicine; Pathology; Radiooncology; Oncological Hem
Jul 6, 2014·Clinical Endocrinology·Petros PerrosUNKNOWN British Thyroid Association
Sep 27, 2014·The Journal of Clinical Endocrinology and Metabolism·Frederik A VerburgHeribert Hänscheid
Nov 5, 2014·Thyroid : Official Journal of the American Thyroid Association·Ryan K OroscoMichael Bouvet
Feb 3, 2015·The Journal of Clinical Endocrinology and Metabolism·Ewa RuelJulie Ann Sosa
Jun 17, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mohamed Abdelgadir AdamJulie A Sosa
Jul 3, 2015·Thyroid : Official Journal of the American Thyroid Association·Gi Hyeon SeoSun Wook Kim
Jun 16, 2016·Thyroid : Official Journal of the American Thyroid Association·Dania HirschCarlos Benbassat
Feb 1, 2017·Thyroid : Official Journal of the American Thyroid Association·Bin XuRonald A Ghossein

❮ Previous
Next ❯

Citations

Dec 5, 2019·Wiener medizinische Wochenschrift·Amir KurtaranChristina Tugendsam
Aug 20, 2020·Thyroid : Official Journal of the American Thyroid Association·Daniel JacobsSaral Mehra
Nov 11, 2019·European Journal of Nuclear Medicine and Molecular Imaging·O MaasP M Putora
Sep 15, 2020·Cancer Biomarkers : Section a of Disease Markers·Shujing LiJing Liu
Dec 1, 2020·Clinical Oncology : a Journal of the Royal College of Radiologists·F Eilsberger, F A Verburg
Jun 24, 2018·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Daniel A Pryma

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Thyroid : Official Journal of the American Thyroid Association
Jacqueline JonklaasNational Thyroid Cancer Treatment Cooperative Study Group
Kaku igaku. The Japanese journal of nuclear medicine
K IkekuboT Mori
Acta Radiologica. Supplementum
G HILTONE E Pochin
© 2022 Meta ULC. All rights reserved