PMID: 8599293Jan 1, 1995Paper

A maximal central venous oxygen saturation (SvO2max) for the surgical patient

Acta Anaesthesiologica Scandinavica. Supplementum
M JenstrupNiels H Secher

Abstract

Before induction of anaesthesia, 23 patients scheduled for major abdominal surgery had blood samples drawn from a central venous catheter for oxygen saturation (SvO2) after graded infusion of isotonic saline. The infusion of saline was continued until further administration resulted in a stable SvO2 (SvO2max). The SvO2 increased from 69 (53-83) to 72 (66-83) % (median and range; P < 0.0001), when the patients received 10 (0-26) mL.kg-1, average 500 mL, of saline. At the same time central venous haematocrit decreased from 38 (32-47) to 36 (23-47) % which suggests that the intravascular volume was expanded by 420 (180-3070) mL or by 72 (18-174) % of the administered volume. The results demonstrate that volume expansion by saline can establish a maximal venous oxygen saturation in the surgical patient.

References

Nov 1, 1992·Clinical Physiology·J Jacobsen, N H Secher
Nov 1, 1992·Clinical and Experimental Pharmacology & Physiology·N H SecherS Matzen
Apr 1, 1992·Acta Anaesthesiologica Scandinavica·R G Hahn
Oct 1, 1991·Acta Anaesthesiologica Scandinavica·G PerkoN H Secher
May 1, 1995·Acta Anaesthesiologica Scandinavica·F JónssonN H Secher
Jul 1, 1993·Scandinavian Journal of Clinical and Laboratory Investigation·P MadsenN H Secher
Feb 1, 1993·Scandinavian Journal of Clinical and Laboratory Investigation·P MadsenN H Secher

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Citations

Mar 29, 2007·Acta Anaesthesiologica Scandinavica·M Bundgaard-NielsenH Kehlet
Jan 13, 2006·Clinical and Experimental Pharmacology & Physiology·Niels H Secher, Johannes J Van Lieshout
Aug 13, 2009·Anesthesiology·Stephen J Shepherd, Rupert M Pearse
Dec 17, 2009·Acta Anaesthesiologica Scandinavica·M Bundgaard-NielsenH Kehlet
Aug 13, 2005·Acta Anaesthesiologica Scandinavica·T KrantzN H Secher
Jan 7, 2010·European Journal of Applied Physiology·Jasper TruijenJohannes J van Lieshout
Apr 29, 2000·Acta Anaesthesiologica Scandinavica·T KrantzN H Secher
Nov 26, 2010·The Journal of Physiology·S VolianitisN H Secher
Jun 13, 2015·BMC Anesthesiology·Lars Stryhn BjerregaardJens Christian Nilsson
Oct 27, 2006·British Journal of Anaesthesia·M Bundgaard-NielsenH Kehlet

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