A measles virus vaccine strain derivative as a novel oncolytic agent against breast cancer

Breast Cancer Research and Treatment
C J McDonaldEvanthia Galanis

Abstract

Breast cancer is the most common malignancy and the second leading cause of female cancer mortality in the United States. There is an urgent need for development of novel therapeutic approaches. In this study, we investigated the antitumor potential of a novel viral agent, an attenuated strain of measles virus deriving from the Edmonston vaccine lineage, genetically engineered to produce carcinoembryonic antigen (CEA) against breast cancer. CEA production as the virus replicates can serve as a marker of viral gene expression. Infection of a variety of breast cancer cell lines including MDA-MB-231, MCF7 and SkBr3 at different multiplicities of infection (MOIs) from 0.1 to 10 resulted in significant cytopathic effect consisting of extensive syncytia formation and massive cell death at 72-96 h from infection. All breast cancer lines overexpressed the measles virus receptor CD46 and supported robust viral replication, which correlated with CEA production. TUNEL assays indicated an apoptotic mechanism of syncytial death. The efficacy of this approach in vivo was examined in a subcutaneous Balb C/nude mouse model of MDA-MB-231 cells. Intravenous administration of MV-CEA at a total dose of 1.2 x 10(7) TCID50 resulted in statistically ...Continue Reading

References

Feb 1, 1991·The Journal of General Virology·T F WildR Buckland
Feb 1, 1968·Journal of the National Cancer Institute·L A DethlefsenM L Mendelsohn
Jun 1, 1995·Journal of Virology·L M EsolenD E Griffin
Nov 1, 1994·The Journal of Infectious Diseases·F T Cutts, L E Markowitz
Mar 4, 2000·Molecular Immunology·K JurianzM Kirschfink
Sep 6, 2000·Nature·H TatsuoY Yanagi
Jul 17, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G N HortobagyiM C Hung
May 2, 2002·Nature Medicine·Kah-Whye PengStephen J Russell
Jul 5, 2002·Journal of Virology·Urs SchneiderRoberto Cattaneo
Jan 9, 2004·International Journal of Cancer. Journal International Du Cancer·Neil K RushmereRobert I Nicholson
Sep 21, 2004·Cancer Immunology, Immunotherapy : CII·Zahra MadjdIan Spendlove
Jan 22, 2005·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Feb 3, 2005·Nature Biotechnology·Takafumi NakamuraStephen J Russell
May 7, 2005·The Journal of Steroid Biochemistry and Molecular Biology·A MatsumuraP D Darbre
Jun 17, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Huayi HuangJoseph Geradts

❮ Previous
Next ❯

Citations

Jun 28, 2011·Cancer Gene Therapy·S BossowG Ungerechts
Jan 7, 2010·Molecular Therapy : the Journal of the American Society of Gene Therapy·Xin MengKenzaburo Tani
May 28, 2009·Molecular Therapy : the Journal of the American Society of Gene Therapy·Ianko D IankovEvanthia Galanis
Apr 7, 2011·Molecular Therapy : the Journal of the American Society of Gene Therapy·Mathias F LeberGuy Ungerechts
Feb 16, 2012·Molecular Therapy : the Journal of the American Society of Gene Therapy·Ianko D IankovEvanthia Galanis
Apr 16, 2013·BioMed Research International·Nicolas BoisgeraultMarc Grégoire
Aug 22, 2014·Human Gene Therapy·Zineb BelcaidRob C Hoeben
Jan 8, 2013·Expert Opinion on Biological Therapy·Pavlos MsaouelEvanthia Galanis
Aug 27, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Manish R PatelRobert A Kratzke
Jan 15, 2013·Translational Research : the Journal of Laboratory and Clinical Medicine·Manish R Patel, Robert A Kratzke
Jul 19, 2011·Gynecologic Oncology·Andreas D HartkopfUlrich M Lauer
Mar 5, 2008·Journal of Theoretical Biology·Zeljko BajzerDavid Dingli
Mar 10, 2015·Mathematical Biosciences·Karly Jacobsen, Sergei S Pilyugin
Sep 11, 2007·Blood Cells, Molecules & Diseases·Stanimir Vuk-Pavlovic
Nov 1, 2008·The Prostate·Pavlos MsaouelEvanthia Galanis
Dec 8, 2015·Molecular Therapy Oncolytics·Olga V MatveevaPeter M Chumakov
Jan 15, 2016·European Journal of Immunology·Darren Qiancheng TanNaoki Yamamoto
Apr 15, 2014·Virology·Patrycja J LechStephen J Russell
Oct 27, 2016·Viruses·Sarah ArefAdele Fielding
Nov 10, 2016·Vaccines·Kenneth Lundstrom
Jan 29, 2017·Expert Opinion on Biological Therapy·Steven Robinson, Evanthia Galanis
Apr 19, 2017·Vaccines·Kenneth Lundstrom
Jan 1, 2013·Biology·Jean-Baptiste GuillermeJean-François Fonteneau
Oct 1, 2010·Clinical Pharmacology and Therapeutics·E Galanis
Feb 12, 2017·Medical Oncology·Yogesh R SuryawanshiKarim Essani
Jul 24, 2020·International Journal of Molecular Sciences·Kenneth Lundstrom
Mar 20, 2020·Biomedicines·Altijana Hromic-Jahjefendic, Kenneth Lundstrom
Apr 28, 2020·Cancer Cell International·Mohsen KeshavarzAmir Ghaemi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Cancer: Chemo-Resistance

Some cancers are difficult to treat and aggressive including the "triple-negative" breast cancer. This type of cancer is chemoresistant even before chemotherapy begins. Here are the latest discoveries chemo-resistance in breast cancer.