A MecA paralog, YpbH, binds ClpC, affecting both competence and sporulation.

Journal of Bacteriology
Marjan PersuhDavid Dubnau

Abstract

ComK, the master regulator of competence, is degraded by the general stress-related protease ClpCP but must be targeted to this protease by binding to the adapter protein MecA. The genome of Bacillus subtilis contains a paralog of mecA, ypbH. We show in the present study that YpbH, like MecA, binds ClpC and that its elimination or overproduction affects competence and sporulation.

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Citations

Dec 1, 2007·Biomolecular NMR Assignments·Douglas J KojetinJohn Cavanagh
Mar 24, 2004·Journal of Structural Biology·Axel MogkBernd Bukau
Jul 18, 2009·Nature Reviews. Microbiology·Janine KirsteinKürşad Turgay
Sep 22, 2009·The Journal of Biological Chemistry·Ziqing MeiYigong Shi
Oct 6, 2009·The Journal of Biological Chemistry·Feng WangYigong Shi
Dec 17, 2008·Journal of Bacteriology·Saurabh K GargPeter Zuber
Oct 23, 2003·Annual Review of Cell and Developmental Biology·Susan Gottesman
Feb 25, 2003·Proceedings of the National Academy of Sciences of the United States of America·Tilman SchlothauerKürşad Turgay
Sep 29, 2009·Research in Microbiology·Noël Molière, Kürşad Turgay
Apr 14, 2009·Journal of Molecular Biology·Douglas J KojetinJohn Cavanagh
Mar 10, 2006·The EMBO Journal·Janine KirsteinKürşad Turgay
Jun 21, 2014·Environmental Microbiology·Lalit K SinghYogendra Singh
Feb 5, 2013·Current Opinion in Microbiology·Aurelia Battesti, Susan Gottesman
Sep 30, 2004·Cell·Robert T SauerTania A Baker
Jan 21, 2004·Journal of Molecular Recognition : JMR·Rebecca L Rich, David G Myszka
Sep 13, 2008·Molecular Microbiology·Janine KirsteinKürşad Turgay
Dec 20, 2005·The Journal of Biological Chemistry·Fredrik I AnderssonAdrian K Clarke

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