PMID: 9659635Jul 11, 1998Paper

A mechanical and histomorphometric analysis of bone bonding by hydroxyapatite-coated strain gages

Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research
D L WilsonG A Battraw

Abstract

Identification of the strains controlling bone remodeling is important for determining ways to prevent bone loss due to load deprivation, or implant placement. Long-term monitoring of strains can potentially provide the best information. Glues are resorbed within 2-3 weeks. Two formulations of microcrystalline hydroxyapatite (HA) were used to attach strain gages to rat femora to assess their long-term in vivo strain measurement capability. Seven male rats received HA-coated gages, and 2 animals underwent a sham procedure. The gages were prepared using a published technique and placed on the antero-lateral aspect of the left femora. After 6-7 weeks, the animals were euthanized and both femora explanted. Gages were attached to the right femora with cyanoacrylate. All femora were tested in cantilever bending, then embedded, sectioned, and stained with mineralized bone stain. The undecalcified sections were examined using transmitted and ultraviolet light microscopy. Mechanical testing showed one HA formulation provided 70-100% bonding. Histology showed intimate contact between the gage and bone surface. Histomorphometry indicated increased bone activity under the gage compared to the remaining bone, the controls, and the shams. Th...Continue Reading

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Citations

May 17, 2000·Journal of Biomedical Materials Research·J A SzivekP L Anderson
Apr 25, 2001·Journal of Biomedical Materials Research·B A RabkinB P Halloran
Mar 15, 2019·PeerJ·Lingwei HuangMikko A J Finnilä

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