A Mechanical Brain Damage Framework Used to Model Abnormal Brain Tau Protein Accumulations of National Football League Players

Annals of Biomedical Engineering
M F HorstemeyerR K Prabhu

Abstract

A mechanics-based brain damage framework is used to model the abnormal accumulation of hyperphosphorylated p-tau associated with chronic traumatic encephalopathy within the brains of deceased National Football League (NFL) players studied at Boston University and to provide a framework for understanding the damage mechanisms. p-tau damage is formulated as the multiplicative decomposition of three independently evolving damage internal state variables (ISVs): nucleation related to number density, growth related to the average area, and coalescence related to the nearest neighbor distance. The ISVs evolve under different rates for three well known mechanical boundary conditions, which in themselves introduce three different rates making a total of nine scenarios, that we postulate are related to brain damage progression: (1) monotonic overloads, (2) cyclic fatigue which corresponds to repetitive impacts, and (3) creep which is correlated to damage accumulation over time. Different NFL player positions are described to capture the different types of damage progression. Skill position players, such as quarterbacks, are expected to exhibit a greater p-tau protein accumulation during low cycle fatigue (higher amplitude impacts with a...Continue Reading

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Citations

Oct 21, 2018·Annals of Biomedical Engineering·Taylor C HarrisEllen Kuhl
May 23, 2020·Annals of Biomedical Engineering·Bethany Rowson, Stefan M Duma
Sep 6, 2019·Annals of Biomedical Engineering·Mark F HorstemeyerRaj K Prabhu
Oct 2, 2020·Annals of Biomedical Engineering·Arthur MaerlenderAdam Hinthorne
Feb 27, 2021·Computer Methods in Biomechanics and Biomedical Engineering·A BakhtiarydavijaniR K Prabhu
Mar 4, 2021·Annals of Biomedical Engineering·Xingyuan HuangZhihua Cai
Feb 25, 2021·Journal of Biomechanical Engineering·Ashley MazurkiewiczOren E Petel
Apr 25, 2021·Journal of the Mechanical Behavior of Biomedical Materials·K L JohnsonYuanyuan Duan

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