Abstract
A mechanics-based brain damage framework is used to model the abnormal accumulation of hyperphosphorylated p-tau associated with chronic traumatic encephalopathy within the brains of deceased National Football League (NFL) players studied at Boston University and to provide a framework for understanding the damage mechanisms. p-tau damage is formulated as the multiplicative decomposition of three independently evolving damage internal state variables (ISVs): nucleation related to number density, growth related to the average area, and coalescence related to the nearest neighbor distance. The ISVs evolve under different rates for three well known mechanical boundary conditions, which in themselves introduce three different rates making a total of nine scenarios, that we postulate are related to brain damage progression: (1) monotonic overloads, (2) cyclic fatigue which corresponds to repetitive impacts, and (3) creep which is correlated to damage accumulation over time. Different NFL player positions are described to capture the different types of damage progression. Skill position players, such as quarterbacks, are expected to exhibit a greater p-tau protein accumulation during low cycle fatigue (higher amplitude impacts with a...Continue Reading
References
Dec 20, 2003·Neurosurgery·Elliot J PellmanDouglas W Robertson
Jul 1, 2005·Neurosurgery·Bennet I OmaluCyril H Wecht
Nov 1, 2005·Medical Engineering & Physics·M KohandelJ M Drake
Sep 26, 2006·Journal of Biomechanical Engineering·F ShenH K Chan
Dec 29, 2007·Neurosurgery·Jason P MihalikKevin M Guskiewicz
Jun 19, 2009·Journal of Neuropathology and Experimental Neurology·Ann C McKeeRobert A Stern
Nov 11, 2010·Journal of Athletic Training·Joseph J CriscoRichard M Greenwald
Jul 27, 2011·Journal of Neurotrauma·Steven P BroglioChristopher Randolph
Aug 30, 2011·Journal of Biomechanics·Joseph J CriscoRichard M Greenwald
Oct 14, 2011·Annals of Biomedical Engineering·James R FunkStefan M Duma
Nov 9, 2011·PM & R : the Journal of Injury, Function, and Rehabilitation·Robert A SternAnn C McKee
Dec 5, 2012·Brain : a Journal of Neurology·Ann C McKeeRobert C Cantu
Jun 14, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Ann C McKee, Meghan E Robinson
Aug 27, 2014·Journal of Neurotrauma·Christine M BaughRobert A Stern
Apr 24, 2015·Brain Pathology·Ann C McKeeVictor E Alvarez
Jul 23, 2015·Nature·Ling ZhaoKang Zhang
Sep 8, 2015·Nature Materials·Laura SchaedelManuel Théry
Nov 12, 2015·Brain Research·Vikram PuvennaDamir Janigro
Dec 17, 2015·Acta Neuropathologica·Ann C McKeeUNKNOWN TBI/CTE group
Feb 6, 2016·Orthopaedic Journal of Sports Medicine·John T NathansonTanvir Choudhri
Jul 26, 2017·JAMA : the Journal of the American Medical Association·Jesse MezAnn C McKee
Oct 21, 2018·Annals of Biomedical Engineering·Taylor C HarrisEllen Kuhl
Jan 22, 2019·Nature Medicine·Oliver PreischeUNKNOWN Dominantly Inherited Alzheimer Network
Citations
Oct 21, 2018·Annals of Biomedical Engineering·Taylor C HarrisEllen Kuhl
May 23, 2020·Annals of Biomedical Engineering·Bethany Rowson, Stefan M Duma
Sep 6, 2019·Annals of Biomedical Engineering·Mark F HorstemeyerRaj K Prabhu
Oct 2, 2020·Annals of Biomedical Engineering·Arthur MaerlenderAdam Hinthorne
Feb 6, 2021·Journal of Biomechanics·K A ZimmermanM Ghajari
Feb 27, 2021·Computer Methods in Biomechanics and Biomedical Engineering·A BakhtiarydavijaniR K Prabhu
Mar 4, 2021·Annals of Biomedical Engineering·Xingyuan HuangZhihua Cai
Feb 25, 2021·Journal of Biomechanical Engineering·Ashley MazurkiewiczOren E Petel
Apr 25, 2021·Journal of the Mechanical Behavior of Biomedical Materials·K L JohnsonYuanyuan Duan
Oct 15, 2020·Annals of Biomedical Engineering·Nicole Phillips, Joseph J Crisco