A mechanism for arteriolar remodeling based on maintenance of smooth muscle cell activation

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Jens Christian Brings JacobsenNiels-Henrik Holstein-Rathlou

Abstract

Structural adaptation in arterioles is part of normal vascular physiology but is also seen in disease states such as hypertension. Smooth muscle cell (SMC) activation has been shown to be central to microvascular remodeling. We hypothesize that, in a remodeling process driven by SMC activation, stress sensitivity of the vascular wall is a key element in the process of achieving a stable vascular structure. We address whether the adaptive changes in arterioles under different conditions can arise through a common mechanism: remodeling in a stress-sensitive wall driven by a shift in SMC activation. We present a simple dynamic model and show that structural remodeling of the vessel radius by rearrangement of the wall material around a lumen of a different diameter and driven by differences in SMC activation can lead to vascular structures similar to those observed experimentally under various conditions. The change in structure simultaneously leads to uniform levels of circumferential wall stress and wall strain, despite differences in transmural pressure. A simulated vasoconstriction caused by increased SMC activation leads to inward remodeling, whereas outward remodeling follows relaxation of the vascular wall. The results are i...Continue Reading

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Citations

Mar 16, 2012·Interface Focus·Jens Christian Brings JacobsenNiels-Henrik Holstein-Rathlou
Mar 1, 2012·Hypertension·Justin P ZachariahRamachandran S Vasan
Dec 1, 2012·Basic Research in Cardiology·Massimiliano ManciniPaolo G Camici
Feb 22, 2012·Journal of the American Society of Hypertension : JASH·Tamara M ParaviciniRhian M Touyz
Nov 3, 2010·Progress in Biophysics and Molecular Biology·Sarah L WatersFrans N van de Vosse
Dec 4, 2008·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Jens Christian Brings JacobsenNiels-Henrik Holstein-Rathlou
Jul 8, 2011·Basic & Clinical Pharmacology & Toxicology·Michael J Mulvany
Oct 15, 2011·Basic & Clinical Pharmacology & Toxicology·Timothy W SecombAxel R Pries
Sep 16, 2011·Basic & Clinical Pharmacology & Toxicology·Jens C B Jacobsen, Niels-Henrik Holstein-Rathlou
Jun 28, 2012·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Amanda J LeBlancJames B Hoying
Apr 4, 2014·CPT: Pharmacometrics & Systems Pharmacology·J TangH C M Boonen
Mar 13, 2012·Experimental Gerontology·Angelo Scuteri, Edward G Lakatta
Jun 4, 2016·Physiological Reports·Christian B PoulsenJens Christian B Jacobsen
Nov 9, 2017·Frontiers in Physiology·Bettina ReglinAxel R Pries
May 19, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Anika KleinJens Christian Brings Jacobsen
Jun 5, 2010·Journal of Occupational and Environmental Medicine·Kristine KrajnakMichael L Kashon
May 27, 2015·Physiological Reports·Jens Christian B Jacobsen, Charlotte M Sorensen
Jan 28, 2020·American Journal of Physiology. Renal Physiology·Sophie MøllerCharlotte M Sorensen
Nov 5, 2014·Physiology·Axel R Pries, Timothy W Secomb

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