A mechanism for epigenetic control of DNA replication

Genes & Development
Courtney G SansamChristopher L Sansam

Abstract

DNA replication origins in hyperacetylated euchromatin fire preferentially during early S phase. However, how acetylation controls DNA replication timing is unknown. TICRR/TRESLIN is an essential protein required for the initiation of DNA replication. Here, we report that TICRR physically interacts with the acetyl-histone binding bromodomain (BRD) and extraterminal (BET) proteins BRD2 and BRD4. Abrogation of this interaction impairs TICRR binding to acetylated chromatin and disrupts normal S-phase progression. Our data reveal a novel function for BET proteins and establish the TICRR-BET interaction as a potential mechanism for epigenetic control of DNA replication.

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Citations

Mar 9, 2019·Genes·Dominik Boos, Pedro Ferreira
Sep 4, 2019·Nature Reviews. Molecular Cell Biology·Claire MarchalDavid M Gilbert
Mar 20, 2019·Genes·Ichiro Hiratani, Saori Takahashi
Jul 6, 2019·Frontiers in Oncology·Qin YuQing-Peng Kong
Jul 25, 2018·The Journal of Biological Chemistry·Sumeet PoudelMichael Leffak
Jul 28, 2020·Trends in Genetics : TIG·Patroula NathanailidouZoi Lygerou
Feb 21, 2021·Scientific Reports·Pedro FerreiraDominik Boos
Aug 3, 2020·Trends in Genetics : TIG·Qiliang Ding, Amnon Koren
Aug 30, 2021·Biochimica Et Biophysica Acta. Reviews on Cancer·Samantha Cruz-RuizMario Zurita
Sep 23, 2021·Experimental & Molecular Medicine·Seo Yun LeeKyle M Miller
Nov 21, 2021·Nature Communications·Qiliang DingAmnon Koren

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