A mechanism for the anti-fibrogenic effects of the pregnane X receptor (PXR) in the liver: inhibition of NF-kappaB?

Toxicology
A AxonMatthew C Wright

Abstract

The liver is susceptible to chronic damage through exposure to a variety of toxins (e.g. alcohol) and viruses (e.g. hepatitis C). Obesity, autoimmune diseases (e.g. autoimmune hepatitis) and a variety of genetic diseases (e.g. Wilson's disease) also lead to chronic liver damage. This damage results in scarring fibrogenesis, structural disruption and functional impairment of the organ. Recent work suggests that there is cross-talk between the PXR and NF-kappaB pathways. This cross-talk may explain the observation that PXR activators inhibit liver fibrosis in in vitro and in vivo animal models of the disease. This reveiw will focus on the two transcription factors and their potential interaction.

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Citations

Aug 20, 2010·The Journal of Pharmacology and Experimental Therapeutics·Gang HuJeff L Staudinger
Feb 1, 2011·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Barbara RengaStefano Fiorucci
Apr 15, 2010·Pharmacology & Therapeutics·Gernot ZollnerMichael Trauner
Jan 13, 2009·British Journal of Pharmacology·Gernot Zollner, Michael Trauner
May 12, 2010·Liver International : Official Journal of the International Association for the Study of the Liver·Christian Rust, Ulrich Beuers
May 23, 2012·Trends in Pharmacological Sciences·Jie ChengFrank J Gonzalez

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