A mechanism for the inactivation of Ca2+/calmodulin-dependent protein kinase II during prolonged seizure activity and its consequence after the recovery from seizure activity in rats in vivo

Neuroscience
Y YamagataK Obata

Abstract

Seizure is a form of excessive neuronal excitation and seizure-induced neuronal damage has profound effects on the prognosis of epilepsy. In various seizure models, the inactivation of Ca2+/calmodulin-dependent protein kinase II (CaMKII) occurs during seizure activity preceding neuronal cell death. CaMKII is a multifunctional protein kinase enriched in the brain and involved in various ways the regulation of neuronal activity. CaMKII inactivation during seizure activity may modify neuronal cell survival after seizure. However, the mechanism for CaMKII inactivation and its consequence after seizure recovery remain to be elucidated yet. In the present study, we employed a prolonged seizure model by systemic injection of kainic acid into rats and biochemically examined the activity state of CaMKII. In status epilepticus induced by kainic acid, not only the inactivation of CaMKII in brain homogenate, but also a shift in the distribution of CaMKII protein from the soluble to particulate fraction occurred in both hippocampus and parietal cortex. The particulate CaMKII showed a large decrease in the specific activity and a concurrent large increase in the autophosphorylation ratio at Thr-286 (alpha) and at Thr-287 (beta). In contrast,...Continue Reading

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Citations

Oct 22, 2008·Anesthesia and Analgesia·Logan J VossHeidi E Kirsch
Aug 5, 2014·Trends in Neurosciences·A J Robison
Mar 14, 2007·Current Opinion in Neurology·David Murdoch
Jun 6, 2009·Expert Review of Neurotherapeutics·Nisha NagarkattiRobert J DeLorenzo
Dec 14, 2007·Annals of the New York Academy of Sciences·H NikizadV Jevtovic-Todorovic
Feb 22, 2014·Advances in Colloid and Interface Science·David R SlochowerPaul A Janmey
Feb 1, 2017·Proceedings of the National Academy of Sciences of the United States of America·Christopher H ThompsonAlfred L George
May 27, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Hirofumi MitsuyamaHiroyuki Tsutsui
Sep 15, 2018·International Journal of Molecular Sciences·Jie-Hua Xu, Feng-Ru Tang
Jan 20, 2021·Clinical Genetics·Andrey V MarakhonovMikhail Yu Skoblov
Mar 29, 2021·Brain Research Bulletin·Martina Proietti Onori, Geeske M van Woerden
Jun 2, 2021·Epilepsia·Laura LibrizziMarco de Curtis
Oct 13, 2006·Science's STKE : Signal Transduction Knowledge Environment·James O McNamaraA Soren Leonard

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