A mechanism for the specific immunogenicity of heat shock protein-chaperoned peptides

Science
R Suto, P K Srivastava

Abstract

Endogenously synthesized antigenic determinants are generally presented on major histocompatibility complex (MHC) class I molecules, whereas exogenous determinants are presented by MHC class II molecules. Here, it is shown that exogenous antigens chaperoned by a heat shock protein can be channeled into the endogenous pathway, presented by MHC class I molecules, and recognized by CD8+ T lymphocytes. This pathway is functional only in a subset of macrophages among the cell types tested. These observations provide a basis for the tumor-specific and virus-specific immunogenicity of cognate heat shock protein preparations and offer a mechanism for the classical phenomenon of cross-priming.

References

Mar 15, 1984·International Journal of Cancer. Journal International Du Cancer·P K Srivastava, M R Das
Apr 12, 1994·Proceedings of the National Academy of Sciences of the United States of America·H UdonoP K Srivastava
Nov 1, 1993·Journal of Immunotherapy with Emphasis on Tumor Immunology : Official Journal of the Society for Biological Therapy·N E BlachereP K Srivastava
Oct 1, 1993·The Journal of Experimental Medicine·H Udono, P K Srivastava

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Citations

Jan 27, 1997·International Journal of Cancer. Journal International Du Cancer·J RobertL Du Pasquier
Sep 27, 2000·International Journal of Cancer. Journal International Du Cancer·S JanetzkiP K Srivastava
Jan 1, 1997·Springer Seminars in Immunopathology·M Corr, H Tighe
Mar 1, 1996·Journal of Clinical Immunology·C V Harding
Apr 1, 1996·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·B HendersonA R Coates
Apr 29, 1998·Biotherapy·M HaradaK Nomoto
Jan 15, 1999·Pathology Oncology Research : POR·C Soti, P Csermely
Feb 27, 2008·European Archives of Psychiatry and Clinical Neuroscience·Jung Jin KimTae-Youn Jun
Jul 1, 2011·Immunologic Research·Sudesh PawariaRobert Julian Binder
Oct 19, 2010·Cell Stress & Chaperones·Arulkumaran ShanmugamRaj K Tiwari
Dec 2, 2010·Cell Stress & Chaperones·Elisa TramentozziPaola Finotti
Oct 12, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Junying WangYongli Yu
Jun 10, 1996·Journal of Immunological Methods·I SakitaS G Nathenson
Jul 1, 1996·Trends in Cell Biology·D B WilliamsW K Suh
Dec 10, 2003·Experimental Hematology·Warren D Shlomchik
Jan 17, 2004·Experimental Hematology·John M Goldman
Nov 11, 2003·Trends in Microbiology·Ulrike K Rapp, Stefan H E Kaufmann
Jun 24, 2003·Atherosclerosis·David J LambGordon A A Ferns
Aug 23, 2002·Journal of Immunological Methods·Song-Dong MengGeorge F Gao
Apr 17, 2003·Developmental and Comparative Immunology·Jacques Robert
Aug 30, 2002·Molecular Immunology·Monique Grommé, Jacques Neefjes
Aug 29, 2000·Immunopharmacology·P Moseley
Apr 6, 1999·Pharmacology & Therapeutics·B R MinevM S Mitchell
Jul 13, 2000·Veterinary Immunology and Immunopathology·B L PappalardoE B Breitschwerdt
Sep 25, 2002·Immunology Letters·Xiaohong ChenXuetao Cao
Mar 24, 1998·Immunology Today·H TigheE Raz

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