PMID: 2631Mar 1, 1976

A mechanism for tobacco smoke-induced allergy

The Journal of Allergy and Clinical Immunology
K F Keller, R J Doyle

Abstract

Normal CFW mice, when exposed to tobacco smoke, showed a significantly increased susceptibility to the lethal effects of histamine. The LD50 for mice subjected to smoke was 45 mg/kg of histamine, whereas in normal CFW mice the LD50 was 1,100 mg/kg. The histamine susceptibility of smoked mice was markedly diminished by injecting the animals with isoproterenol. Normal CFW mice, as well as sham control mice, exhibited an epinephrine-induced hyperglycemia, whereas the blood glucose values for smoked mice given epinephrine were essentially the same as those for sham mice given only saline. This observation indicates that tobacco smoke may contain a component which causes an autonomic imbalance, hence rendering the mice more susceptible to histamine. This tobacco smoke-induced allergy is probably related to a blockade of adrenergic receptors and not to an immunologic phenomenon.

Citations

Dec 1, 2000·Nutrition Research Reviews·R J Moy
Dec 16, 1998·Journal of the American College of Nutrition·R A Anderson
Dec 2, 2004·Journal of Pediatric Gastroenterology and Nutrition·Jean ReyBerthold Koletzko
Jan 1, 1984·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·R R Cardoso
Feb 6, 2004·Environmental Research·William M GershanTimothy F Lowry
Feb 1, 1984·The Journal of Allergy and Clinical Immunology·S B LehrerJ E Salvaggio
Aug 1, 1976·Pediatric Annals·D L Miller, G A Friday

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