A mechanism of virus-induced demyelination.

Interdisciplinary Perspectives on Infectious Diseases
Jayasri Das Sarma

Abstract

Myelin forms an insulating sheath surrounding axons in the central and peripheral nervous systems and is essential for rapid propagation of neuronal action potentials. Demyelination is an acquired disorder in which normally formed myelin degenerates, exposing axons to the extracellular environment. The result is dysfunction of normal neuron-to-neuron communication and in many cases, varying degrees of axonal degeneration. Numerous central nervous system demyelinating disorders exist, including multiple sclerosis. Although demyelination is the major manifestation of most of the demyelinating diseases, recent studies have clearly documented concomitant axonal loss to varying degrees resulting in long-term disability. Axonal injury may occur secondary to myelin damage (outside-in model) or myelin damage may occur secondary to axonal injury (inside-out model). Viral induced demyelination models, has provided unique imminent into the cellular mechanisms of myelin destruction. They illustrate mechanisms of viral persistence, including latent infections, virus reactivation and viral-induced tissue damage. These studies have also provided excellent paradigms to study the interactions between the immune system and the central nervous sy...Continue Reading

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Citations

Mar 2, 2011·Journal of Biomedical Science·Yu-Fen TsengWei-June Chen
May 21, 2014·Proceedings of the National Academy of Sciences of the United States of America·Milton L GreenbergMichael D Cahalan
Aug 28, 2013·Journal of Neurovirology·Jayasri Das Sarma
Jan 7, 2016·Frontiers in Cellular Neuroscience·Lawrence C KenyonJayasri Das Sarma
May 17, 2011·Journal of Neuropathology and Experimental Neurology·Kenneth S ShindlerJayasri Das Sarma
Jul 19, 2013·Clinical & Developmental Immunology·Dhriti ChatterjeeJayasri Das Sarma
Jul 11, 2016·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Kaushiki BiswasJayasri Das Sarma
Feb 2, 2013·ZooKeys·Stjepan Krčmar
Jan 24, 2017·Frontiers in Cellular and Infection Microbiology·Juan JovelGane Ka-Shu Wong
Jun 2, 2017·Journal of Biosciences·Jibin SadasivanJayasri DAS Sarma
Nov 8, 2017·Stem Cells International·Woon Ryoung KimDongho Geum
Oct 6, 2020·SN Comprehensive Clinical Medicine·Shweta JakhmolaHem Chandra Jha
Feb 7, 2021·Journal of Neurovirology·Debanjana Chakravarty, Jayasri Das Sarma

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Datasets Mentioned

BETA
AF201929
9629812

Methods Mentioned

BETA
fluorescence microscopy
glycosylation

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