A mechanistic hydro-epidemiological model of liver fluke risk

Journal of the Royal Society, Interface
Ludovica BeltrameThorsten Wagener

Abstract

The majority of existing models for predicting disease risk in response to climate change are empirical. These models exploit correlations between historical data, rather than explicitly describing relationships between cause and response variables. Therefore, they are unsuitable for capturing impacts beyond historically observed variability and have limited ability to guide interventions. In this study, we integrate environmental and epidemiological processes into a new mechanistic model, taking the widespread parasitic disease of fasciolosis as an example. The model simulates environmental suitability for disease transmission at a daily time step and 25 m resolution, explicitly linking the parasite life cycle to key weather-water-environment conditions. Using epidemiological data, we show that the model can reproduce observed infection levels in time and space for two case studies in the UK. To overcome data limitations, we propose a calibration approach combining Monte Carlo sampling and expert opinion, which allows constraint of the model in a process-based way, including a quantification of uncertainty. The simulated disease dynamics agree with information from the literature, and comparison with a widely used empirical ri...Continue Reading

References

Feb 26, 2005·Tropical Medicine & International Health : TM & IH·Song LiangDongchuan Qiu
Sep 10, 2005·International Journal for Parasitology·S Mas-ComaM A Valero
Apr 21, 2006·Ecology Letters·Sonia AltizerPejman Rohani
Apr 27, 1883·Science·C S Minot
Feb 22, 2008·Nature·Kate E JonesPeter Daszak
Dec 8, 2009·Science·James O Lloyd-SmithBryan T Grenfell
Jan 21, 2011·PloS One·Naomi J FoxMichael R Hutchings
Mar 1, 2010·Animal : an International Journal of Animal Bioscience·J van DijkP J Skuce
Feb 19, 2014·Wiener klinische Wochenschrift·Helmut SattmannHeinrich Prosl
Aug 16, 2014·The Veterinary Record·N SelemetasT de Waal
Jan 1, 2012·Animals : an Open Access Journal From MDPI·Naomi J FoxMichael R Hutchings
Mar 25, 2016·Scientific Reports·Joanne TurnerMatthew Baylis
May 11, 2016·Proceedings of the National Academy of Sciences of the United States of America·Javier Perez-SaezAndrea Rinaldo
Sep 10, 2016·Science·M C UrbanJ M J Travis
Jul 30, 2017·Trends in Parasitology·Kathryn M HusonMark W Robinson
Sep 9, 2017·The Veterinary Record·Jenny Hull
Apr 14, 2018·Advances in Water Resources·Andrea RinaldoIgnacio Rodriguez-Iturbe

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